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Intergenerational Cycle of Obesity and Diabetes: How Can We Reduce the Burdens of These Conditions on the Health of Future Generations?

Prepregnancy overweight or obesity and excessive gestational weight gain have been associated with increased risk of maternal and neonatal complications. Moreover, offspring from obese women are more likely to develop obesity, diabetes mellitus, and cardiovascular diseases in their lifetime. Gestati...

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Autores principales: Battista, Marie-Claude, Hivert, Marie-France, Duval, Karine, Baillargeon, Jean-Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205776/
https://www.ncbi.nlm.nih.gov/pubmed/22110473
http://dx.doi.org/10.1155/2011/596060
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author Battista, Marie-Claude
Hivert, Marie-France
Duval, Karine
Baillargeon, Jean-Patrice
author_facet Battista, Marie-Claude
Hivert, Marie-France
Duval, Karine
Baillargeon, Jean-Patrice
author_sort Battista, Marie-Claude
collection PubMed
description Prepregnancy overweight or obesity and excessive gestational weight gain have been associated with increased risk of maternal and neonatal complications. Moreover, offspring from obese women are more likely to develop obesity, diabetes mellitus, and cardiovascular diseases in their lifetime. Gestational diabetes mellitus (GDM) is one of the most common complications associated with obesity and appears to have a direct impact on the future metabolic health of the child. Fetal programming of metabolic function induced by obesity and GDM may have intergenerational effect and thus perpetuate the epidemic of cardiometabolic conditions. The present paper thus aims at discussing the impact of maternal obesity and GDM on the developmental programming of obesity and metabolic disorders in the offspring. The main interventions designed to reduce maternal obesity and GDM and their ability to break the vicious circle that perpetuates the transmission of obesity and metabolic conditions to the next generations are also addressed.
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spelling pubmed-32057762011-11-22 Intergenerational Cycle of Obesity and Diabetes: How Can We Reduce the Burdens of These Conditions on the Health of Future Generations? Battista, Marie-Claude Hivert, Marie-France Duval, Karine Baillargeon, Jean-Patrice Exp Diabetes Res Review Article Prepregnancy overweight or obesity and excessive gestational weight gain have been associated with increased risk of maternal and neonatal complications. Moreover, offspring from obese women are more likely to develop obesity, diabetes mellitus, and cardiovascular diseases in their lifetime. Gestational diabetes mellitus (GDM) is one of the most common complications associated with obesity and appears to have a direct impact on the future metabolic health of the child. Fetal programming of metabolic function induced by obesity and GDM may have intergenerational effect and thus perpetuate the epidemic of cardiometabolic conditions. The present paper thus aims at discussing the impact of maternal obesity and GDM on the developmental programming of obesity and metabolic disorders in the offspring. The main interventions designed to reduce maternal obesity and GDM and their ability to break the vicious circle that perpetuates the transmission of obesity and metabolic conditions to the next generations are also addressed. Hindawi Publishing Corporation 2011 2011-10-29 /pmc/articles/PMC3205776/ /pubmed/22110473 http://dx.doi.org/10.1155/2011/596060 Text en Copyright © 2011 Marie-Claude Battista et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Battista, Marie-Claude
Hivert, Marie-France
Duval, Karine
Baillargeon, Jean-Patrice
Intergenerational Cycle of Obesity and Diabetes: How Can We Reduce the Burdens of These Conditions on the Health of Future Generations?
title Intergenerational Cycle of Obesity and Diabetes: How Can We Reduce the Burdens of These Conditions on the Health of Future Generations?
title_full Intergenerational Cycle of Obesity and Diabetes: How Can We Reduce the Burdens of These Conditions on the Health of Future Generations?
title_fullStr Intergenerational Cycle of Obesity and Diabetes: How Can We Reduce the Burdens of These Conditions on the Health of Future Generations?
title_full_unstemmed Intergenerational Cycle of Obesity and Diabetes: How Can We Reduce the Burdens of These Conditions on the Health of Future Generations?
title_short Intergenerational Cycle of Obesity and Diabetes: How Can We Reduce the Burdens of These Conditions on the Health of Future Generations?
title_sort intergenerational cycle of obesity and diabetes: how can we reduce the burdens of these conditions on the health of future generations?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205776/
https://www.ncbi.nlm.nih.gov/pubmed/22110473
http://dx.doi.org/10.1155/2011/596060
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