Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP

X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D1A which encodes SAP. SAP functions in signalling pathways elicited by the SLAM family of leukocyte receptors. A defining feature of XLP is exquisite sensitivity to infection with EBV, a B-lymphotropi...

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Detalles Bibliográficos
Autores principales: Palendira, Umaimainthan, Low, Carol, Chan, Anna, Hislop, Andrew D., Ho, Edwin, Phan, Tri Giang, Deenick, Elissa, Cook, Matthew C., Riminton, D. Sean, Choo, Sharon, Loh, Richard, Alvaro, Frank, Booth, Claire, Gaspar, H. Bobby, Moretta, Alessandro, Khanna, Rajiv, Rickinson, Alan B., Tangye, Stuart G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206011/
https://www.ncbi.nlm.nih.gov/pubmed/22069374
http://dx.doi.org/10.1371/journal.pbio.1001187

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