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Status of B-Vitamins and Homocysteine in Diabetic Retinopathy: Association with Vitamin-B12 Deficiency and Hyperhomocysteinemia

Diabetic retinopathy (DR) is a common cause of blindness. Although many studies have indicated an association between homocysteine and DR, the results so far have been equivocal. Amongst the many determinants of homocysteine, B-vitamin status was shown to be a major confounding factor, yet very litt...

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Autores principales: Satyanarayana, Alleboena, Balakrishna, Nagalla, Pitla, Sujatha, Reddy, Paduru Yadagiri, Mudili, Sivaprasad, Lopamudra, Pratti, Suryanarayana, Palla, Viswanath, Kalluru, Ayyagari, Radha, Reddy, Geereddy Bhanuprakash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206053/
https://www.ncbi.nlm.nih.gov/pubmed/22069468
http://dx.doi.org/10.1371/journal.pone.0026747
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author Satyanarayana, Alleboena
Balakrishna, Nagalla
Pitla, Sujatha
Reddy, Paduru Yadagiri
Mudili, Sivaprasad
Lopamudra, Pratti
Suryanarayana, Palla
Viswanath, Kalluru
Ayyagari, Radha
Reddy, Geereddy Bhanuprakash
author_facet Satyanarayana, Alleboena
Balakrishna, Nagalla
Pitla, Sujatha
Reddy, Paduru Yadagiri
Mudili, Sivaprasad
Lopamudra, Pratti
Suryanarayana, Palla
Viswanath, Kalluru
Ayyagari, Radha
Reddy, Geereddy Bhanuprakash
author_sort Satyanarayana, Alleboena
collection PubMed
description Diabetic retinopathy (DR) is a common cause of blindness. Although many studies have indicated an association between homocysteine and DR, the results so far have been equivocal. Amongst the many determinants of homocysteine, B-vitamin status was shown to be a major confounding factor, yet very little is known about its relationship to DR. In the present study, we, therefore, investigated the status of B-vitamins and homocysteine in DR. A cross-sectional case–control study was conducted with 100 normal control (CN) subjects and 300 subjects with type-2 diabetes (T2D). Of the 300 subjects with T2D, 200 had retinopathy (DR) and 100 did not (DNR). After a complete ophthalmic examination including fundus fluorescein angiography, the clinical profile and the blood levels of all B-vitamins and homocysteine were analyzed. While mean plasma homocysteine levels were found to be higher in T2D patients compared with CN subjects, homocysteine levels were particularly high in the DR group. There were no group differences in the blood levels of vitamins B1 and B2. Although the plasma vitamin-B6 and folic acid levels were significantly lower in the DNR and DR groups compared with the CN group, there were no significant differences between the diabetes groups. Interestingly, plasma vitamin-B12 levels were found to be significantly lower in the diabetes groups compared with the CN group; further, the levels were significantly lower in the DR group compared with the DNR group. Higher homocysteine levels were significantly associated with lower vitamin-B12 and folic acid but not with other B-vitamins. Additionally, hyperhomocysteinemia and vitamin-B12 deficiency did not seem to be related to subjects' age, body mass index, or duration of diabetes. These results thus suggest a possible association between vitamin-B12 deficiency and hyperhomocysteinemia in DR. Further, the data indicate that vitamin-B12 deficiency could be an independent risk factor for DR.
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spelling pubmed-32060532011-11-08 Status of B-Vitamins and Homocysteine in Diabetic Retinopathy: Association with Vitamin-B12 Deficiency and Hyperhomocysteinemia Satyanarayana, Alleboena Balakrishna, Nagalla Pitla, Sujatha Reddy, Paduru Yadagiri Mudili, Sivaprasad Lopamudra, Pratti Suryanarayana, Palla Viswanath, Kalluru Ayyagari, Radha Reddy, Geereddy Bhanuprakash PLoS One Research Article Diabetic retinopathy (DR) is a common cause of blindness. Although many studies have indicated an association between homocysteine and DR, the results so far have been equivocal. Amongst the many determinants of homocysteine, B-vitamin status was shown to be a major confounding factor, yet very little is known about its relationship to DR. In the present study, we, therefore, investigated the status of B-vitamins and homocysteine in DR. A cross-sectional case–control study was conducted with 100 normal control (CN) subjects and 300 subjects with type-2 diabetes (T2D). Of the 300 subjects with T2D, 200 had retinopathy (DR) and 100 did not (DNR). After a complete ophthalmic examination including fundus fluorescein angiography, the clinical profile and the blood levels of all B-vitamins and homocysteine were analyzed. While mean plasma homocysteine levels were found to be higher in T2D patients compared with CN subjects, homocysteine levels were particularly high in the DR group. There were no group differences in the blood levels of vitamins B1 and B2. Although the plasma vitamin-B6 and folic acid levels were significantly lower in the DNR and DR groups compared with the CN group, there were no significant differences between the diabetes groups. Interestingly, plasma vitamin-B12 levels were found to be significantly lower in the diabetes groups compared with the CN group; further, the levels were significantly lower in the DR group compared with the DNR group. Higher homocysteine levels were significantly associated with lower vitamin-B12 and folic acid but not with other B-vitamins. Additionally, hyperhomocysteinemia and vitamin-B12 deficiency did not seem to be related to subjects' age, body mass index, or duration of diabetes. These results thus suggest a possible association between vitamin-B12 deficiency and hyperhomocysteinemia in DR. Further, the data indicate that vitamin-B12 deficiency could be an independent risk factor for DR. Public Library of Science 2011-11-01 /pmc/articles/PMC3206053/ /pubmed/22069468 http://dx.doi.org/10.1371/journal.pone.0026747 Text en Satyanarayana et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Satyanarayana, Alleboena
Balakrishna, Nagalla
Pitla, Sujatha
Reddy, Paduru Yadagiri
Mudili, Sivaprasad
Lopamudra, Pratti
Suryanarayana, Palla
Viswanath, Kalluru
Ayyagari, Radha
Reddy, Geereddy Bhanuprakash
Status of B-Vitamins and Homocysteine in Diabetic Retinopathy: Association with Vitamin-B12 Deficiency and Hyperhomocysteinemia
title Status of B-Vitamins and Homocysteine in Diabetic Retinopathy: Association with Vitamin-B12 Deficiency and Hyperhomocysteinemia
title_full Status of B-Vitamins and Homocysteine in Diabetic Retinopathy: Association with Vitamin-B12 Deficiency and Hyperhomocysteinemia
title_fullStr Status of B-Vitamins and Homocysteine in Diabetic Retinopathy: Association with Vitamin-B12 Deficiency and Hyperhomocysteinemia
title_full_unstemmed Status of B-Vitamins and Homocysteine in Diabetic Retinopathy: Association with Vitamin-B12 Deficiency and Hyperhomocysteinemia
title_short Status of B-Vitamins and Homocysteine in Diabetic Retinopathy: Association with Vitamin-B12 Deficiency and Hyperhomocysteinemia
title_sort status of b-vitamins and homocysteine in diabetic retinopathy: association with vitamin-b12 deficiency and hyperhomocysteinemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206053/
https://www.ncbi.nlm.nih.gov/pubmed/22069468
http://dx.doi.org/10.1371/journal.pone.0026747
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