Genetic and Epigenetic Modifications of Sox2 Contribute to the Invasive Phenotype of Malignant Gliomas

We undertook this study to understand how the transcription factor Sox2 contributes to the malignant phenotype of glioblastoma multiforme (GBM), the most aggressive primary brain tumor. We initially looked for unbalanced genomic rearrangements in the Sox2 locus in 42 GBM samples and found that Sox2...

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Detalles Bibliográficos
Autores principales: Alonso, Marta M., Diez-Valle, Ricardo, Manterola, Lorea, Rubio, Angel, Liu, Dan, Cortes-Santiago, Nahir, Urquiza, Leire, Jauregi, Patricia, de Munain, Adolfo Lopez, Sampron, Nicolás, Aramburu, Ander, Tejada-Solís, Sonia, Vicente, Carmen, Odero, María D., Bandrés, Eva, García-Foncillas, Jesús, Idoate, Miguel A., Lang, Frederick F., Fueyo, Juan, Gomez-Manzano, Candelaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206066/
https://www.ncbi.nlm.nih.gov/pubmed/22069467
http://dx.doi.org/10.1371/journal.pone.0026740

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