The PPARγ Agonist Rosiglitazone Is Antifibrotic for Scleroderma Lung Fibroblasts: Mechanisms of Action and Differential Racial Effects

We present novel data demonstrating that the expression of PPARγ is reduced in lung fibroblasts from black SSc-ILD patients as compared to white patients. Activating PPARγ with the agonist rosiglitazone increased the expression of MMP-1 and inhibited collagen type I in lung fibroblasts isolated from...

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Detalles Bibliográficos
Autores principales: Bogatkevich, Galina S., Highland, Kristin B., Akter, Tanjina, Silver, Richard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206324/
https://www.ncbi.nlm.nih.gov/pubmed/22135743
http://dx.doi.org/10.1155/2012/545172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206324/
https://www.ncbi.nlm.nih.gov/pubmed/22135743
http://dx.doi.org/10.1155/2012/545172

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