Integrin Trafficking and Tumor Progression

Integrins are major mediators of cancer cell adhesion to extracellular matrix. Through this interaction, integrins play critical roles in cell migration, invasion, metastasis, and resistance to apoptosis during tumor progression. Recent studies highlight the importance of integrin trafficking, endoc...

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Detalles Bibliográficos
Autores principales: Shin, Sejeong, Wolgamott, Laura, Yoon, Sang-Oh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206329/
https://www.ncbi.nlm.nih.gov/pubmed/22121362
http://dx.doi.org/10.1155/2012/516789
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author Shin, Sejeong
Wolgamott, Laura
Yoon, Sang-Oh
author_facet Shin, Sejeong
Wolgamott, Laura
Yoon, Sang-Oh
author_sort Shin, Sejeong
collection PubMed
description Integrins are major mediators of cancer cell adhesion to extracellular matrix. Through this interaction, integrins play critical roles in cell migration, invasion, metastasis, and resistance to apoptosis during tumor progression. Recent studies highlight the importance of integrin trafficking, endocytosis and recycling, for the functions of integrins in cancer cells. Understanding the molecular mechanisms of integrin trafficking is pivotal for understanding tumor progression and for the development of anticancer drugs.
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spelling pubmed-32063292011-11-25 Integrin Trafficking and Tumor Progression Shin, Sejeong Wolgamott, Laura Yoon, Sang-Oh Int J Cell Biol Review Article Integrins are major mediators of cancer cell adhesion to extracellular matrix. Through this interaction, integrins play critical roles in cell migration, invasion, metastasis, and resistance to apoptosis during tumor progression. Recent studies highlight the importance of integrin trafficking, endocytosis and recycling, for the functions of integrins in cancer cells. Understanding the molecular mechanisms of integrin trafficking is pivotal for understanding tumor progression and for the development of anticancer drugs. Hindawi Publishing Corporation 2012 2011-10-30 /pmc/articles/PMC3206329/ /pubmed/22121362 http://dx.doi.org/10.1155/2012/516789 Text en Copyright © 2012 Sejeong Shin et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Shin, Sejeong
Wolgamott, Laura
Yoon, Sang-Oh
Integrin Trafficking and Tumor Progression
title Integrin Trafficking and Tumor Progression
title_full Integrin Trafficking and Tumor Progression
title_fullStr Integrin Trafficking and Tumor Progression
title_full_unstemmed Integrin Trafficking and Tumor Progression
title_short Integrin Trafficking and Tumor Progression
title_sort integrin trafficking and tumor progression
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206329/
https://www.ncbi.nlm.nih.gov/pubmed/22121362
http://dx.doi.org/10.1155/2012/516789
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