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Class III PI-3-kinase activates phospholipase D in an amino acid–sensing mTORC1 pathway

The rapamycin-sensitive mammalian target of rapamycin (mTOR) complex, mTORC1, regulates cell growth in response to mitogenic signals and amino acid availability. Phospholipase D (PLD) and its product, phosphatidic acid, have been established as mediators of mitogenic activation of mTORC1. In this st...

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Detalles Bibliográficos
Autores principales:	Yoon, Mee-Sup, Du, Guangwei, Backer, Jonathan M., Frohman, Michael A., Chen, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2011
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206351/ https://www.ncbi.nlm.nih.gov/pubmed/22024166 http://dx.doi.org/10.1083/jcb.201107033

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