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Ulcerative Granular Cell Tumor: A Clinicopathological and Immunohistochemical Study

Granular cell tumor (GCT) is uncommonly presented with cutaneous ulcer. We examined the clinicopathological and immunohistochemical features of this ulcerative form in fourteen cases that may raise the awareness of this variant. The study included 11 males and 3 females with a mean age 31.5 ± 7.42 y...

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Autores principales: El-Khalawany, Mohamed, Mosbeh, Al-Sadat, Abd-Al Salam, Fatma, Abou-Bakr, Amany
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206371/
https://www.ncbi.nlm.nih.gov/pubmed/22132340
http://dx.doi.org/10.1155/2011/497648
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author El-Khalawany, Mohamed
Mosbeh, Al-Sadat
Abd-Al Salam, Fatma
Abou-Bakr, Amany
author_facet El-Khalawany, Mohamed
Mosbeh, Al-Sadat
Abd-Al Salam, Fatma
Abou-Bakr, Amany
author_sort El-Khalawany, Mohamed
collection PubMed
description Granular cell tumor (GCT) is uncommonly presented with cutaneous ulcer. We examined the clinicopathological and immunohistochemical features of this ulcerative form in fourteen cases that may raise the awareness of this variant. The study included 11 males and 3 females with a mean age 31.5 ± 7.42 years. All cases were presented with large solitary ulcer with indurated base, elevated border, skin colored margin, and necrotic floor. Twelve lesions were located on the extremities and two lesions on the genital region. Histologically, the lesions showed dermal infiltrate composed of large polygonal cells with granular cytoplasm and characteristic infiltration of the dermal muscles in all cases. Immunostaining showed positive reaction for S100 (14/14), NSE (14/14), CD68 (5/14), and Vimentin (7/14) while HMB45, CK, EMA, and Desmin were negative. We hope that this paper increases the awareness of ulcerative GCT and consider it in the differential diagnosis of ulcerative lesions.
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spelling pubmed-32063712011-11-30 Ulcerative Granular Cell Tumor: A Clinicopathological and Immunohistochemical Study El-Khalawany, Mohamed Mosbeh, Al-Sadat Abd-Al Salam, Fatma Abou-Bakr, Amany J Skin Cancer Clinical Study Granular cell tumor (GCT) is uncommonly presented with cutaneous ulcer. We examined the clinicopathological and immunohistochemical features of this ulcerative form in fourteen cases that may raise the awareness of this variant. The study included 11 males and 3 females with a mean age 31.5 ± 7.42 years. All cases were presented with large solitary ulcer with indurated base, elevated border, skin colored margin, and necrotic floor. Twelve lesions were located on the extremities and two lesions on the genital region. Histologically, the lesions showed dermal infiltrate composed of large polygonal cells with granular cytoplasm and characteristic infiltration of the dermal muscles in all cases. Immunostaining showed positive reaction for S100 (14/14), NSE (14/14), CD68 (5/14), and Vimentin (7/14) while HMB45, CK, EMA, and Desmin were negative. We hope that this paper increases the awareness of ulcerative GCT and consider it in the differential diagnosis of ulcerative lesions. Hindawi Publishing Corporation 2011 2011-11-01 /pmc/articles/PMC3206371/ /pubmed/22132340 http://dx.doi.org/10.1155/2011/497648 Text en Copyright © 2011 Mohamed El-Khalawany et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
El-Khalawany, Mohamed
Mosbeh, Al-Sadat
Abd-Al Salam, Fatma
Abou-Bakr, Amany
Ulcerative Granular Cell Tumor: A Clinicopathological and Immunohistochemical Study
title Ulcerative Granular Cell Tumor: A Clinicopathological and Immunohistochemical Study
title_full Ulcerative Granular Cell Tumor: A Clinicopathological and Immunohistochemical Study
title_fullStr Ulcerative Granular Cell Tumor: A Clinicopathological and Immunohistochemical Study
title_full_unstemmed Ulcerative Granular Cell Tumor: A Clinicopathological and Immunohistochemical Study
title_short Ulcerative Granular Cell Tumor: A Clinicopathological and Immunohistochemical Study
title_sort ulcerative granular cell tumor: a clinicopathological and immunohistochemical study
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206371/
https://www.ncbi.nlm.nih.gov/pubmed/22132340
http://dx.doi.org/10.1155/2011/497648
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