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Ulcerative Granular Cell Tumor: A Clinicopathological and Immunohistochemical Study
Granular cell tumor (GCT) is uncommonly presented with cutaneous ulcer. We examined the clinicopathological and immunohistochemical features of this ulcerative form in fourteen cases that may raise the awareness of this variant. The study included 11 males and 3 females with a mean age 31.5 ± 7.42 y...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206371/ https://www.ncbi.nlm.nih.gov/pubmed/22132340 http://dx.doi.org/10.1155/2011/497648 |
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author | El-Khalawany, Mohamed Mosbeh, Al-Sadat Abd-Al Salam, Fatma Abou-Bakr, Amany |
author_facet | El-Khalawany, Mohamed Mosbeh, Al-Sadat Abd-Al Salam, Fatma Abou-Bakr, Amany |
author_sort | El-Khalawany, Mohamed |
collection | PubMed |
description | Granular cell tumor (GCT) is uncommonly presented with cutaneous ulcer. We examined the clinicopathological and immunohistochemical features of this ulcerative form in fourteen cases that may raise the awareness of this variant. The study included 11 males and 3 females with a mean age 31.5 ± 7.42 years. All cases were presented with large solitary ulcer with indurated base, elevated border, skin colored margin, and necrotic floor. Twelve lesions were located on the extremities and two lesions on the genital region. Histologically, the lesions showed dermal infiltrate composed of large polygonal cells with granular cytoplasm and characteristic infiltration of the dermal muscles in all cases. Immunostaining showed positive reaction for S100 (14/14), NSE (14/14), CD68 (5/14), and Vimentin (7/14) while HMB45, CK, EMA, and Desmin were negative. We hope that this paper increases the awareness of ulcerative GCT and consider it in the differential diagnosis of ulcerative lesions. |
format | Online Article Text |
id | pubmed-3206371 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32063712011-11-30 Ulcerative Granular Cell Tumor: A Clinicopathological and Immunohistochemical Study El-Khalawany, Mohamed Mosbeh, Al-Sadat Abd-Al Salam, Fatma Abou-Bakr, Amany J Skin Cancer Clinical Study Granular cell tumor (GCT) is uncommonly presented with cutaneous ulcer. We examined the clinicopathological and immunohistochemical features of this ulcerative form in fourteen cases that may raise the awareness of this variant. The study included 11 males and 3 females with a mean age 31.5 ± 7.42 years. All cases were presented with large solitary ulcer with indurated base, elevated border, skin colored margin, and necrotic floor. Twelve lesions were located on the extremities and two lesions on the genital region. Histologically, the lesions showed dermal infiltrate composed of large polygonal cells with granular cytoplasm and characteristic infiltration of the dermal muscles in all cases. Immunostaining showed positive reaction for S100 (14/14), NSE (14/14), CD68 (5/14), and Vimentin (7/14) while HMB45, CK, EMA, and Desmin were negative. We hope that this paper increases the awareness of ulcerative GCT and consider it in the differential diagnosis of ulcerative lesions. Hindawi Publishing Corporation 2011 2011-11-01 /pmc/articles/PMC3206371/ /pubmed/22132340 http://dx.doi.org/10.1155/2011/497648 Text en Copyright © 2011 Mohamed El-Khalawany et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study El-Khalawany, Mohamed Mosbeh, Al-Sadat Abd-Al Salam, Fatma Abou-Bakr, Amany Ulcerative Granular Cell Tumor: A Clinicopathological and Immunohistochemical Study |
title | Ulcerative Granular Cell Tumor: A Clinicopathological and Immunohistochemical Study |
title_full | Ulcerative Granular Cell Tumor: A Clinicopathological and Immunohistochemical Study |
title_fullStr | Ulcerative Granular Cell Tumor: A Clinicopathological and Immunohistochemical Study |
title_full_unstemmed | Ulcerative Granular Cell Tumor: A Clinicopathological and Immunohistochemical Study |
title_short | Ulcerative Granular Cell Tumor: A Clinicopathological and Immunohistochemical Study |
title_sort | ulcerative granular cell tumor: a clinicopathological and immunohistochemical study |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206371/ https://www.ncbi.nlm.nih.gov/pubmed/22132340 http://dx.doi.org/10.1155/2011/497648 |
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