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Research on Trypanosoma cruzi and Analysis of Inflammatory Infiltrate in Esophagus and Colon from Chronic Chagasic Patients with and without Mega

To compare parasitism and inflammatory process in esophagus and colon from chronic chagasic patients, immunohistochemistry was carried out to research for T. cruzi and to evaluate the inflammatory infiltrate in the muscular and myenteric plexus in 39 esophagi (20 with and 19 without megaesophagus) a...

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Autores principales: Côbo, Eliângela de Castro, Silveira, Thales Parenti, Micheletti, Adilha Misson, Crema, Eduardo, Adad, Sheila Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206379/
https://www.ncbi.nlm.nih.gov/pubmed/22131997
http://dx.doi.org/10.1155/2012/232646
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author Côbo, Eliângela de Castro
Silveira, Thales Parenti
Micheletti, Adilha Misson
Crema, Eduardo
Adad, Sheila Jorge
author_facet Côbo, Eliângela de Castro
Silveira, Thales Parenti
Micheletti, Adilha Misson
Crema, Eduardo
Adad, Sheila Jorge
author_sort Côbo, Eliângela de Castro
collection PubMed
description To compare parasitism and inflammatory process in esophagus and colon from chronic chagasic patients, immunohistochemistry was carried out to research for T. cruzi and to evaluate the inflammatory infiltrate in the muscular and myenteric plexus in 39 esophagi (20 with and 19 without megaesophagus) and 50 colons (25 with and 25 without megacolon). The frequency of T. cruzi in megaesophagus was 20%, and in megacolon it was 4%. No amastigotes were found in organs without mega; considering the total of esophagi (with and without mega), the frequency of T. cruzi would be 10% and 2% in the colon. Myositis and ganglionitis were more frequent and intense in organs with mega compared to those without mega, and in esophagus compared to colon. Qualitatively, inflammatory infiltration in esophagus and colon, with or without mega, was similar, consisting predominantly of T lymphocytes (CD3+), scarce macrophages (CD68+), and rare B lymphocytes (CD20+).
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spelling pubmed-32063792011-11-30 Research on Trypanosoma cruzi and Analysis of Inflammatory Infiltrate in Esophagus and Colon from Chronic Chagasic Patients with and without Mega Côbo, Eliângela de Castro Silveira, Thales Parenti Micheletti, Adilha Misson Crema, Eduardo Adad, Sheila Jorge J Trop Med Research Article To compare parasitism and inflammatory process in esophagus and colon from chronic chagasic patients, immunohistochemistry was carried out to research for T. cruzi and to evaluate the inflammatory infiltrate in the muscular and myenteric plexus in 39 esophagi (20 with and 19 without megaesophagus) and 50 colons (25 with and 25 without megacolon). The frequency of T. cruzi in megaesophagus was 20%, and in megacolon it was 4%. No amastigotes were found in organs without mega; considering the total of esophagi (with and without mega), the frequency of T. cruzi would be 10% and 2% in the colon. Myositis and ganglionitis were more frequent and intense in organs with mega compared to those without mega, and in esophagus compared to colon. Qualitatively, inflammatory infiltration in esophagus and colon, with or without mega, was similar, consisting predominantly of T lymphocytes (CD3+), scarce macrophages (CD68+), and rare B lymphocytes (CD20+). Hindawi Publishing Corporation 2012 2011-10-30 /pmc/articles/PMC3206379/ /pubmed/22131997 http://dx.doi.org/10.1155/2012/232646 Text en Copyright © 2012 Eliângela de Castro Côbo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Côbo, Eliângela de Castro
Silveira, Thales Parenti
Micheletti, Adilha Misson
Crema, Eduardo
Adad, Sheila Jorge
Research on Trypanosoma cruzi and Analysis of Inflammatory Infiltrate in Esophagus and Colon from Chronic Chagasic Patients with and without Mega
title Research on Trypanosoma cruzi and Analysis of Inflammatory Infiltrate in Esophagus and Colon from Chronic Chagasic Patients with and without Mega
title_full Research on Trypanosoma cruzi and Analysis of Inflammatory Infiltrate in Esophagus and Colon from Chronic Chagasic Patients with and without Mega
title_fullStr Research on Trypanosoma cruzi and Analysis of Inflammatory Infiltrate in Esophagus and Colon from Chronic Chagasic Patients with and without Mega
title_full_unstemmed Research on Trypanosoma cruzi and Analysis of Inflammatory Infiltrate in Esophagus and Colon from Chronic Chagasic Patients with and without Mega
title_short Research on Trypanosoma cruzi and Analysis of Inflammatory Infiltrate in Esophagus and Colon from Chronic Chagasic Patients with and without Mega
title_sort research on trypanosoma cruzi and analysis of inflammatory infiltrate in esophagus and colon from chronic chagasic patients with and without mega
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206379/
https://www.ncbi.nlm.nih.gov/pubmed/22131997
http://dx.doi.org/10.1155/2012/232646
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