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Emerging Role of PPAR-β/δ in Inflammatory Process Associated to Experimental Periodontitis
The aim of the present study was to evaluate the contribution of peroxisome proliferator-activated receptor (PPAR-β/δ) in animal model of periodontitis. Male Sprague-Dawley rats were lightly anaesthetized with pentobarbitone (35 mg/kg). Sterile, 2-0 black braided silk thread was placed around the ce...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206391/ https://www.ncbi.nlm.nih.gov/pubmed/22131647 http://dx.doi.org/10.1155/2011/787159 |
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author | Di Paola, Rosanna Briguglio, Francesco Paterniti, Irene Mazzon, Emanuela Oteri, Giacomo Militi, David Cordasco, Giancarlo Cuzzocrea, Salvatore |
author_facet | Di Paola, Rosanna Briguglio, Francesco Paterniti, Irene Mazzon, Emanuela Oteri, Giacomo Militi, David Cordasco, Giancarlo Cuzzocrea, Salvatore |
author_sort | Di Paola, Rosanna |
collection | PubMed |
description | The aim of the present study was to evaluate the contribution of peroxisome proliferator-activated receptor (PPAR-β/δ) in animal model of periodontitis. Male Sprague-Dawley rats were lightly anaesthetized with pentobarbitone (35 mg/kg). Sterile, 2-0 black braided silk thread was placed around the cervix of the lower left first molar and knotted medially. Animals received GW0742 (0.3 mg/kg, 10% DMSO, i.p. after the ligature placement and daily for eight days). At day 8, the gingivomucosal tissue encircling the mandibular first molar was removed. One the eighth day after placement of the ligature, we evaluated (1) NF-κB expression, (2) cytokines expression, (3) iNOS expression, (5) the nitration of tyrosine, (6) apoptosis, and (8) the degree of gingivomucosal tissues injury. Administration of GW0742 significantly decreased all of the parameters of inflammation as described above. Taken together, these results demonstrate that GW0742 exerts an anti-inflammatory role during experimental periodontitis and is able to ameliorate the tissue damage. |
format | Online Article Text |
id | pubmed-3206391 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32063912011-11-30 Emerging Role of PPAR-β/δ in Inflammatory Process Associated to Experimental Periodontitis Di Paola, Rosanna Briguglio, Francesco Paterniti, Irene Mazzon, Emanuela Oteri, Giacomo Militi, David Cordasco, Giancarlo Cuzzocrea, Salvatore Mediators Inflamm Research Article The aim of the present study was to evaluate the contribution of peroxisome proliferator-activated receptor (PPAR-β/δ) in animal model of periodontitis. Male Sprague-Dawley rats were lightly anaesthetized with pentobarbitone (35 mg/kg). Sterile, 2-0 black braided silk thread was placed around the cervix of the lower left first molar and knotted medially. Animals received GW0742 (0.3 mg/kg, 10% DMSO, i.p. after the ligature placement and daily for eight days). At day 8, the gingivomucosal tissue encircling the mandibular first molar was removed. One the eighth day after placement of the ligature, we evaluated (1) NF-κB expression, (2) cytokines expression, (3) iNOS expression, (5) the nitration of tyrosine, (6) apoptosis, and (8) the degree of gingivomucosal tissues injury. Administration of GW0742 significantly decreased all of the parameters of inflammation as described above. Taken together, these results demonstrate that GW0742 exerts an anti-inflammatory role during experimental periodontitis and is able to ameliorate the tissue damage. Hindawi Publishing Corporation 2011 2011-11-01 /pmc/articles/PMC3206391/ /pubmed/22131647 http://dx.doi.org/10.1155/2011/787159 Text en Copyright © 2011 Rosanna Di Paola et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Di Paola, Rosanna Briguglio, Francesco Paterniti, Irene Mazzon, Emanuela Oteri, Giacomo Militi, David Cordasco, Giancarlo Cuzzocrea, Salvatore Emerging Role of PPAR-β/δ in Inflammatory Process Associated to Experimental Periodontitis |
title | Emerging Role of PPAR-β/δ in Inflammatory Process Associated to Experimental Periodontitis |
title_full | Emerging Role of PPAR-β/δ in Inflammatory Process Associated to Experimental Periodontitis |
title_fullStr | Emerging Role of PPAR-β/δ in Inflammatory Process Associated to Experimental Periodontitis |
title_full_unstemmed | Emerging Role of PPAR-β/δ in Inflammatory Process Associated to Experimental Periodontitis |
title_short | Emerging Role of PPAR-β/δ in Inflammatory Process Associated to Experimental Periodontitis |
title_sort | emerging role of ppar-β/δ in inflammatory process associated to experimental periodontitis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206391/ https://www.ncbi.nlm.nih.gov/pubmed/22131647 http://dx.doi.org/10.1155/2011/787159 |
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