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Social Defeat during Adolescence and Adulthood Differentially Induce BDNF-Regulated Immediate Early Genes

Stressful life events generally enhance the vulnerability for the development of human psychopathologies such as anxiety disorders and depression. The incidence rates of adult mental disorders steeply rises during adolescence in parallel with a structural and functional reorganization of the neural...

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Autores principales: Coppens, Caroline M., Siripornmongcolchai, Taweeporn, Wibrand, Karin, Alme, Maria Nordheim, Buwalda, Bauke, de Boer, Sietse F., Koolhaas, Jaap M., Bramham, Clive R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206404/
https://www.ncbi.nlm.nih.gov/pubmed/22065953
http://dx.doi.org/10.3389/fnbeh.2011.00072
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author Coppens, Caroline M.
Siripornmongcolchai, Taweeporn
Wibrand, Karin
Alme, Maria Nordheim
Buwalda, Bauke
de Boer, Sietse F.
Koolhaas, Jaap M.
Bramham, Clive R.
author_facet Coppens, Caroline M.
Siripornmongcolchai, Taweeporn
Wibrand, Karin
Alme, Maria Nordheim
Buwalda, Bauke
de Boer, Sietse F.
Koolhaas, Jaap M.
Bramham, Clive R.
author_sort Coppens, Caroline M.
collection PubMed
description Stressful life events generally enhance the vulnerability for the development of human psychopathologies such as anxiety disorders and depression. The incidence rates of adult mental disorders steeply rises during adolescence in parallel with a structural and functional reorganization of the neural circuitry underlying stress reactivity. However, the mechanisms underlying susceptibility to stress and manifestation of mental disorders during adolescence are little understood. We hypothesized that heightened sensitivity to stress during adolescence reflects age-dependent differences in the expression of activity-dependent genes involved in synaptic plasticity. Therefore, we compared the effect of social stress during adolescence with social stress in adulthood on the expression of a panel of genes linked to induction of long-term potentiation (LTP) and brain-derived neurotrophic factor (BDNF) signaling. We show that social defeat during adolescence and adulthood differentially regulates expression of the immediate early genes BDNF, Arc, Carp, and Tieg1, as measured by qPCR in tissue lysates from prefrontal cortex, nucleus accumbens, and hippocampus. In the hippocampus, mRNA levels for all four genes were robustly elevated following social defeat in adolescence, whereas none were induced by defeat in adulthood. The relationship to coping style was also examined using adult reactive and proactive coping rats. Gene expression levels of reactive and proactive animals were similar in the prefrontal cortex and hippocampus. However, a trend toward a differential expression of BDNF and Arc mRNA in the nucleus accumbens was detected. BDNF mRNA was increased in the nucleus accumbens of proactive defeated animals, whereas the expression level in reactive defeated animals was comparable to control animals. The results demonstrate striking differences in immediate early gene expression in response to social defeat in adolescent and adult rats.
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spelling pubmed-32064042011-11-07 Social Defeat during Adolescence and Adulthood Differentially Induce BDNF-Regulated Immediate Early Genes Coppens, Caroline M. Siripornmongcolchai, Taweeporn Wibrand, Karin Alme, Maria Nordheim Buwalda, Bauke de Boer, Sietse F. Koolhaas, Jaap M. Bramham, Clive R. Front Behav Neurosci Neuroscience Stressful life events generally enhance the vulnerability for the development of human psychopathologies such as anxiety disorders and depression. The incidence rates of adult mental disorders steeply rises during adolescence in parallel with a structural and functional reorganization of the neural circuitry underlying stress reactivity. However, the mechanisms underlying susceptibility to stress and manifestation of mental disorders during adolescence are little understood. We hypothesized that heightened sensitivity to stress during adolescence reflects age-dependent differences in the expression of activity-dependent genes involved in synaptic plasticity. Therefore, we compared the effect of social stress during adolescence with social stress in adulthood on the expression of a panel of genes linked to induction of long-term potentiation (LTP) and brain-derived neurotrophic factor (BDNF) signaling. We show that social defeat during adolescence and adulthood differentially regulates expression of the immediate early genes BDNF, Arc, Carp, and Tieg1, as measured by qPCR in tissue lysates from prefrontal cortex, nucleus accumbens, and hippocampus. In the hippocampus, mRNA levels for all four genes were robustly elevated following social defeat in adolescence, whereas none were induced by defeat in adulthood. The relationship to coping style was also examined using adult reactive and proactive coping rats. Gene expression levels of reactive and proactive animals were similar in the prefrontal cortex and hippocampus. However, a trend toward a differential expression of BDNF and Arc mRNA in the nucleus accumbens was detected. BDNF mRNA was increased in the nucleus accumbens of proactive defeated animals, whereas the expression level in reactive defeated animals was comparable to control animals. The results demonstrate striking differences in immediate early gene expression in response to social defeat in adolescent and adult rats. Frontiers Research Foundation 2011-11-02 /pmc/articles/PMC3206404/ /pubmed/22065953 http://dx.doi.org/10.3389/fnbeh.2011.00072 Text en Copyright © 2011 Coppens, Siripornmongcolchai, Wibrand, Alme, Buwalda, de Boer, Koolhaas and Bramham. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
spellingShingle Neuroscience
Coppens, Caroline M.
Siripornmongcolchai, Taweeporn
Wibrand, Karin
Alme, Maria Nordheim
Buwalda, Bauke
de Boer, Sietse F.
Koolhaas, Jaap M.
Bramham, Clive R.
Social Defeat during Adolescence and Adulthood Differentially Induce BDNF-Regulated Immediate Early Genes
title Social Defeat during Adolescence and Adulthood Differentially Induce BDNF-Regulated Immediate Early Genes
title_full Social Defeat during Adolescence and Adulthood Differentially Induce BDNF-Regulated Immediate Early Genes
title_fullStr Social Defeat during Adolescence and Adulthood Differentially Induce BDNF-Regulated Immediate Early Genes
title_full_unstemmed Social Defeat during Adolescence and Adulthood Differentially Induce BDNF-Regulated Immediate Early Genes
title_short Social Defeat during Adolescence and Adulthood Differentially Induce BDNF-Regulated Immediate Early Genes
title_sort social defeat during adolescence and adulthood differentially induce bdnf-regulated immediate early genes
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206404/
https://www.ncbi.nlm.nih.gov/pubmed/22065953
http://dx.doi.org/10.3389/fnbeh.2011.00072
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