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Association of genetic variants in the promoter region of genes encoding p22phox (CYBA) and glutamate cysteine ligase catalytic subunit (GCLC) and renal disease in patients with type 1 diabetes mellitus

BACKGROUND: Oxidative stress is recognized as a major pathogenic factor of cellular damage caused by hyperglycemia. NOX/NADPH oxidases generate reactive oxygen species and NOX1, NOX2 and NOX4 isoforms are expressed in kidney and require association with subunit p22phox (encoded by the CYBA gene). In...

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Detalles Bibliográficos
Autores principales:	Vieira, Suzana M, Monteiro, Maria B, Marques, Tatiana, Luna, Ana M, Fortes, Maria A, Nery, Márcia, Queiroz, Márcia, Dib, Sérgio A, Vendramini, Márcio F, Azevedo, Mirela J, Canani, Luis H, Parisi, Maria C, Pavin, Elizabeth J, Giannella-Neto, Daniel, Corrêa-Giannella, Maria L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206419/ https://www.ncbi.nlm.nih.gov/pubmed/21962117 http://dx.doi.org/10.1186/1471-2350-12-129

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