Pathobiology of ALK-negative anaplastic large cell lymphoma

The authors revise the concept of ALK-negative anaplastic large cell lymphoma (ALCL) in the light of the recently updated WHO classification of Tumors of Hematopoietic and Lymphoid Tissues both on biological and clinical grounds. The main histological findings are illustrated as well as the phenotyp...

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Detalles Bibliográficos
Autores principales: Pileri, Stefano A., Agostinelli, Claudio, Bacci, Francesco, Sabattini, Elena, Sagramoso, Carlo, Falini, Brunangelo, Piccaluga, Pier Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206530/
https://www.ncbi.nlm.nih.gov/pubmed/22053281
http://dx.doi.org/10.4081/pr.2011.s2.e5
Descripción
Sumario:The authors revise the concept of ALK-negative anaplastic large cell lymphoma (ALCL) in the light of the recently updated WHO classification of Tumors of Hematopoietic and Lymphoid Tissues both on biological and clinical grounds. The main histological findings are illustrated as well as the phenotypic, molecular and clinical characteristics. Finally, the biological rationale for possible innovative targeted therapies is presented.

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