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How does the NPM1 mutant induce leukemia?
NPM1 is the most frequently mutated gene in AML and the role of the NPM1 mutant in acute myeloid leukemia along with its leukemogenic potential are still under investigation. NPM1 genetic alterations can contribute to leukemogenesis through the direct oncogenic effect of the mutant protein and the c...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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PAGEPress Publications
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206532/ https://www.ncbi.nlm.nih.gov/pubmed/22053282 http://dx.doi.org/10.4081/pr.2011.s2.e6 |