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Myeloid/T-cell acute lymphoblastic leukemia in children and adults
Until recently, few molecular aberrations were recognized in T-cell acute lymphoblastic leukemia (T-ALL) and they were restricted to aberrations involving the T-cell receptor (TCR). The introduction of powerful technologies has allowed to identify novel rearrangements. In this context, we have perfo...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206536/ https://www.ncbi.nlm.nih.gov/pubmed/22053279 http://dx.doi.org/10.4081/pr.2011.s2.e3 |
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author | Chiaretti, Sabina Messina, Monica Tavolaro, Simona Foà, Robin |
author_facet | Chiaretti, Sabina Messina, Monica Tavolaro, Simona Foà, Robin |
author_sort | Chiaretti, Sabina |
collection | PubMed |
description | Until recently, few molecular aberrations were recognized in T-cell acute lymphoblastic leukemia (T-ALL) and they were restricted to aberrations involving the T-cell receptor (TCR). The introduction of powerful technologies has allowed to identify novel rearrangements. In this context, we have performed a gene expression profiling analysis on a relatively large cohort (n=69) of adult patients with a diagnosis of T-ALL. By unsupervised clustering, we identified 5 subgroups. Of these, one branch included 7 patients (10%) whose gene expression profile resembled that of AML. These cases were characterized by the overexpression of a large set of myeloid-related genes, as well as of miR-223. Finally, these patients appear to have an unfavorable clinical course. This newly identified subset of T-ALL cases partly resembles the so-called ETP (early T-precursor) pediatric subgroup: both age groups have in fact a peculiar gene expression profile, an unfavorable outcome and an incidence of about 10%. |
format | Online Article Text |
id | pubmed-3206536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | PAGEPress Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-32065362011-11-03 Myeloid/T-cell acute lymphoblastic leukemia in children and adults Chiaretti, Sabina Messina, Monica Tavolaro, Simona Foà, Robin Pediatr Rep Article Until recently, few molecular aberrations were recognized in T-cell acute lymphoblastic leukemia (T-ALL) and they were restricted to aberrations involving the T-cell receptor (TCR). The introduction of powerful technologies has allowed to identify novel rearrangements. In this context, we have performed a gene expression profiling analysis on a relatively large cohort (n=69) of adult patients with a diagnosis of T-ALL. By unsupervised clustering, we identified 5 subgroups. Of these, one branch included 7 patients (10%) whose gene expression profile resembled that of AML. These cases were characterized by the overexpression of a large set of myeloid-related genes, as well as of miR-223. Finally, these patients appear to have an unfavorable clinical course. This newly identified subset of T-ALL cases partly resembles the so-called ETP (early T-precursor) pediatric subgroup: both age groups have in fact a peculiar gene expression profile, an unfavorable outcome and an incidence of about 10%. PAGEPress Publications 2011-06-22 /pmc/articles/PMC3206536/ /pubmed/22053279 http://dx.doi.org/10.4081/pr.2011.s2.e3 Text en ©Copyright S. Chiaretti et al., 2011 This work is licensed under a Creative Commons Attribution NonCommercial 3.0 License (CC BYNC 3.0). Licensee PAGEPress, Italy |
spellingShingle | Article Chiaretti, Sabina Messina, Monica Tavolaro, Simona Foà, Robin Myeloid/T-cell acute lymphoblastic leukemia in children and adults |
title | Myeloid/T-cell acute lymphoblastic leukemia in children and adults |
title_full | Myeloid/T-cell acute lymphoblastic leukemia in children and adults |
title_fullStr | Myeloid/T-cell acute lymphoblastic leukemia in children and adults |
title_full_unstemmed | Myeloid/T-cell acute lymphoblastic leukemia in children and adults |
title_short | Myeloid/T-cell acute lymphoblastic leukemia in children and adults |
title_sort | myeloid/t-cell acute lymphoblastic leukemia in children and adults |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206536/ https://www.ncbi.nlm.nih.gov/pubmed/22053279 http://dx.doi.org/10.4081/pr.2011.s2.e3 |
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