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Myeloid/T-cell acute lymphoblastic leukemia in children and adults

Until recently, few molecular aberrations were recognized in T-cell acute lymphoblastic leukemia (T-ALL) and they were restricted to aberrations involving the T-cell receptor (TCR). The introduction of powerful technologies has allowed to identify novel rearrangements. In this context, we have perfo...

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Detalles Bibliográficos
Autores principales: Chiaretti, Sabina, Messina, Monica, Tavolaro, Simona, Foà, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206536/
https://www.ncbi.nlm.nih.gov/pubmed/22053279
http://dx.doi.org/10.4081/pr.2011.s2.e3
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author Chiaretti, Sabina
Messina, Monica
Tavolaro, Simona
Foà, Robin
author_facet Chiaretti, Sabina
Messina, Monica
Tavolaro, Simona
Foà, Robin
author_sort Chiaretti, Sabina
collection PubMed
description Until recently, few molecular aberrations were recognized in T-cell acute lymphoblastic leukemia (T-ALL) and they were restricted to aberrations involving the T-cell receptor (TCR). The introduction of powerful technologies has allowed to identify novel rearrangements. In this context, we have performed a gene expression profiling analysis on a relatively large cohort (n=69) of adult patients with a diagnosis of T-ALL. By unsupervised clustering, we identified 5 subgroups. Of these, one branch included 7 patients (10%) whose gene expression profile resembled that of AML. These cases were characterized by the overexpression of a large set of myeloid-related genes, as well as of miR-223. Finally, these patients appear to have an unfavorable clinical course. This newly identified subset of T-ALL cases partly resembles the so-called ETP (early T-precursor) pediatric subgroup: both age groups have in fact a peculiar gene expression profile, an unfavorable outcome and an incidence of about 10%.
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spelling pubmed-32065362011-11-03 Myeloid/T-cell acute lymphoblastic leukemia in children and adults Chiaretti, Sabina Messina, Monica Tavolaro, Simona Foà, Robin Pediatr Rep Article Until recently, few molecular aberrations were recognized in T-cell acute lymphoblastic leukemia (T-ALL) and they were restricted to aberrations involving the T-cell receptor (TCR). The introduction of powerful technologies has allowed to identify novel rearrangements. In this context, we have performed a gene expression profiling analysis on a relatively large cohort (n=69) of adult patients with a diagnosis of T-ALL. By unsupervised clustering, we identified 5 subgroups. Of these, one branch included 7 patients (10%) whose gene expression profile resembled that of AML. These cases were characterized by the overexpression of a large set of myeloid-related genes, as well as of miR-223. Finally, these patients appear to have an unfavorable clinical course. This newly identified subset of T-ALL cases partly resembles the so-called ETP (early T-precursor) pediatric subgroup: both age groups have in fact a peculiar gene expression profile, an unfavorable outcome and an incidence of about 10%. PAGEPress Publications 2011-06-22 /pmc/articles/PMC3206536/ /pubmed/22053279 http://dx.doi.org/10.4081/pr.2011.s2.e3 Text en ©Copyright S. Chiaretti et al., 2011 This work is licensed under a Creative Commons Attribution NonCommercial 3.0 License (CC BYNC 3.0). Licensee PAGEPress, Italy
spellingShingle Article
Chiaretti, Sabina
Messina, Monica
Tavolaro, Simona
Foà, Robin
Myeloid/T-cell acute lymphoblastic leukemia in children and adults
title Myeloid/T-cell acute lymphoblastic leukemia in children and adults
title_full Myeloid/T-cell acute lymphoblastic leukemia in children and adults
title_fullStr Myeloid/T-cell acute lymphoblastic leukemia in children and adults
title_full_unstemmed Myeloid/T-cell acute lymphoblastic leukemia in children and adults
title_short Myeloid/T-cell acute lymphoblastic leukemia in children and adults
title_sort myeloid/t-cell acute lymphoblastic leukemia in children and adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206536/
https://www.ncbi.nlm.nih.gov/pubmed/22053279
http://dx.doi.org/10.4081/pr.2011.s2.e3
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