Flavivirus Cell Entry and Membrane Fusion

Flaviviruses, such as dengue virus and West Nile virus, are enveloped viruses that infect cells through receptor-mediated endocytosis and fusion from within acidic endosomes. The cell entry process of flaviviruses is mediated by the viral E glycoprotein. This short review will address recent advance...

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Autores principales: Smit, Jolanda M., Moesker, Bastiaan, Rodenhuis-Zybert, Izabela, Wilschut, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206597/
https://www.ncbi.nlm.nih.gov/pubmed/22049308
http://dx.doi.org/10.3390/v3020160
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author Smit, Jolanda M.
Moesker, Bastiaan
Rodenhuis-Zybert, Izabela
Wilschut, Jan
author_facet Smit, Jolanda M.
Moesker, Bastiaan
Rodenhuis-Zybert, Izabela
Wilschut, Jan
author_sort Smit, Jolanda M.
collection PubMed
description Flaviviruses, such as dengue virus and West Nile virus, are enveloped viruses that infect cells through receptor-mediated endocytosis and fusion from within acidic endosomes. The cell entry process of flaviviruses is mediated by the viral E glycoprotein. This short review will address recent advances in the understanding of flavivirus cell entry with specific emphasis on the recent study of Zaitseva and coworkers, indicating that anionic lipids might play a crucial role in the fusion process of dengue virus [1].
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spelling pubmed-32065972011-11-02 Flavivirus Cell Entry and Membrane Fusion Smit, Jolanda M. Moesker, Bastiaan Rodenhuis-Zybert, Izabela Wilschut, Jan Viruses Commentary Flaviviruses, such as dengue virus and West Nile virus, are enveloped viruses that infect cells through receptor-mediated endocytosis and fusion from within acidic endosomes. The cell entry process of flaviviruses is mediated by the viral E glycoprotein. This short review will address recent advances in the understanding of flavivirus cell entry with specific emphasis on the recent study of Zaitseva and coworkers, indicating that anionic lipids might play a crucial role in the fusion process of dengue virus [1]. Molecular Diversity Preservation International (MDPI) 2011-02-22 /pmc/articles/PMC3206597/ /pubmed/22049308 http://dx.doi.org/10.3390/v3020160 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Commentary
Smit, Jolanda M.
Moesker, Bastiaan
Rodenhuis-Zybert, Izabela
Wilschut, Jan
Flavivirus Cell Entry and Membrane Fusion
title Flavivirus Cell Entry and Membrane Fusion
title_full Flavivirus Cell Entry and Membrane Fusion
title_fullStr Flavivirus Cell Entry and Membrane Fusion
title_full_unstemmed Flavivirus Cell Entry and Membrane Fusion
title_short Flavivirus Cell Entry and Membrane Fusion
title_sort flavivirus cell entry and membrane fusion
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206597/
https://www.ncbi.nlm.nih.gov/pubmed/22049308
http://dx.doi.org/10.3390/v3020160
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