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Epidemiological features of patients infected with HCV genotype 4 in Poland: Epidemiology of HCV genotype 4 in Poland

BACKGROUND: Hepatitis C genotype 4 (HCV-4) is considered to be rare outside northern Africa and southern Europe. OBJECTIVES: To describe the epidemiological characteristics of patients infected with HCV-4 in Poland. PATIENTS AND METHODS: The study group included 290 patients with HCV-related chronic...

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Autores principales: Chlabicz, Slawomir, Flisiak, Robert, Lapinski, Tadeusz W, Kowalczuk, Oksana, Wiercinska-Drapalo, Alicja, Pytel-Krolczuk, Barbara, Grzeszczuk, Anna, Chyczewski, Lech, Pancewicz, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206688/
https://www.ncbi.nlm.nih.gov/pubmed/22087142
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author Chlabicz, Slawomir
Flisiak, Robert
Lapinski, Tadeusz W
Kowalczuk, Oksana
Wiercinska-Drapalo, Alicja
Pytel-Krolczuk, Barbara
Grzeszczuk, Anna
Chyczewski, Lech
Pancewicz, Joanna
author_facet Chlabicz, Slawomir
Flisiak, Robert
Lapinski, Tadeusz W
Kowalczuk, Oksana
Wiercinska-Drapalo, Alicja
Pytel-Krolczuk, Barbara
Grzeszczuk, Anna
Chyczewski, Lech
Pancewicz, Joanna
author_sort Chlabicz, Slawomir
collection PubMed
description BACKGROUND: Hepatitis C genotype 4 (HCV-4) is considered to be rare outside northern Africa and southern Europe. OBJECTIVES: To describe the epidemiological characteristics of patients infected with HCV-4 in Poland. PATIENTS AND METHODS: The study group included 290 patients with HCV-related chronic liver disease and intravenous drug users with HCV infection recruited in years 2002-2006 in Podlaskie region, north-eastern Poland. In all cases, HCV infection was confirmed by HCV-RNA detection by qualitative nested RT-PCR. HCV genotype was determined by 5'UTR sequencing and comparison with known genotype-specific sequences. RESULTS: HCV 4 was found in 45 (15.5%) of 290 HCV-infected and HCV RNA-positive individuals. 60% of HCV 4 infections occurred in intravenous drug users; 51% of HCV 4-infected patients were also HIV-positive. Among 119 patients whose source of infection was other than drug use, there were 16 (10.5%) HCV 4 cases. Seven (46%) of 13 HCV 4-positive and HIV-negative patients who received combined antiviral treatment had sustained viral response. CONCLUSIONS: HCV 4 exists in eastern Poland, and the infection is frequently related to intravenous drug use and accompanied by HIV infection. HCV 4 also causes a proportion of non-drug-related HCV infections.
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spelling pubmed-32066882011-11-15 Epidemiological features of patients infected with HCV genotype 4 in Poland: Epidemiology of HCV genotype 4 in Poland Chlabicz, Slawomir Flisiak, Robert Lapinski, Tadeusz W Kowalczuk, Oksana Wiercinska-Drapalo, Alicja Pytel-Krolczuk, Barbara Grzeszczuk, Anna Chyczewski, Lech Pancewicz, Joanna Hepat Mon Original Article BACKGROUND: Hepatitis C genotype 4 (HCV-4) is considered to be rare outside northern Africa and southern Europe. OBJECTIVES: To describe the epidemiological characteristics of patients infected with HCV-4 in Poland. PATIENTS AND METHODS: The study group included 290 patients with HCV-related chronic liver disease and intravenous drug users with HCV infection recruited in years 2002-2006 in Podlaskie region, north-eastern Poland. In all cases, HCV infection was confirmed by HCV-RNA detection by qualitative nested RT-PCR. HCV genotype was determined by 5'UTR sequencing and comparison with known genotype-specific sequences. RESULTS: HCV 4 was found in 45 (15.5%) of 290 HCV-infected and HCV RNA-positive individuals. 60% of HCV 4 infections occurred in intravenous drug users; 51% of HCV 4-infected patients were also HIV-positive. Among 119 patients whose source of infection was other than drug use, there were 16 (10.5%) HCV 4 cases. Seven (46%) of 13 HCV 4-positive and HIV-negative patients who received combined antiviral treatment had sustained viral response. CONCLUSIONS: HCV 4 exists in eastern Poland, and the infection is frequently related to intravenous drug use and accompanied by HIV infection. HCV 4 also causes a proportion of non-drug-related HCV infections. Kowsar 2011-03-01 2011-03-01 /pmc/articles/PMC3206688/ /pubmed/22087142 Text en Copyright © 2011, Kowsar M.P. Co. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chlabicz, Slawomir
Flisiak, Robert
Lapinski, Tadeusz W
Kowalczuk, Oksana
Wiercinska-Drapalo, Alicja
Pytel-Krolczuk, Barbara
Grzeszczuk, Anna
Chyczewski, Lech
Pancewicz, Joanna
Epidemiological features of patients infected with HCV genotype 4 in Poland: Epidemiology of HCV genotype 4 in Poland
title Epidemiological features of patients infected with HCV genotype 4 in Poland: Epidemiology of HCV genotype 4 in Poland
title_full Epidemiological features of patients infected with HCV genotype 4 in Poland: Epidemiology of HCV genotype 4 in Poland
title_fullStr Epidemiological features of patients infected with HCV genotype 4 in Poland: Epidemiology of HCV genotype 4 in Poland
title_full_unstemmed Epidemiological features of patients infected with HCV genotype 4 in Poland: Epidemiology of HCV genotype 4 in Poland
title_short Epidemiological features of patients infected with HCV genotype 4 in Poland: Epidemiology of HCV genotype 4 in Poland
title_sort epidemiological features of patients infected with hcv genotype 4 in poland: epidemiology of hcv genotype 4 in poland
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206688/
https://www.ncbi.nlm.nih.gov/pubmed/22087142
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