Predicting In Vivo Anti-Hepatofibrotic Drug Efficacy Based on In Vitro High-Content Analysis

BACKGROUND/AIMS: Many anti-fibrotic drugs with high in vitro efficacies fail to produce significant effects in vivo. The aim of this work is to use a statistical approach to design a numerical predictor that correlates better with in vivo outcomes. METHODS: High-content analysis (HCA) was performed...

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Detalles Bibliográficos
Autores principales: Zheng, Baixue, Tan, Looling, Mo, Xuejun, Yu, Weimiao, Wang, Yan, Tucker-Kellogg, Lisa, Welsch, Roy E., So, Peter T. C., Yu, Hanry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206809/
https://www.ncbi.nlm.nih.gov/pubmed/22073152
http://dx.doi.org/10.1371/journal.pone.0026230

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