Na(+)/K(+)-ATPase Is Present in Scrapie-Associated Fibrils, Modulates PrP Misfolding In Vitro and Links PrP Function and Dysfunction

Transmissible spongiform encephalopathies are characterised by widespread deposition of fibrillar and/or plaque-like forms of the prion protein. These aggregated forms are produced by misfolding of the normal prion protein, PrP(C), to the disease-associated form, PrP(Sc), through mechanisms that rem...

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Detalles Bibliográficos
Autores principales: Graham, James F., Kurian, Dominic, Agarwal, Sonya, Toovey, Lorna, Hunt, Lawrence, Kirby, Louise, Pinheiro, Teresa J. T., Banner, Steven J., Gill, Andrew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206849/
https://www.ncbi.nlm.nih.gov/pubmed/22073199
http://dx.doi.org/10.1371/journal.pone.0026813

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