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Paired Associative Stimulation of the Auditory System: A Proof-Of-Principle Study

BACKGROUND: Paired associative stimulation (PAS) consisting of repeated application of transcranial magnetic stimulation (TMS) pulses and contingent exteroceptive stimuli has been shown to induce neuroplastic effects in the motor and somatosensory system. The objective was to investigate whether the...

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Autores principales: Schecklmann, Martin, Volberg, Gregor, Frank, Gabriele, Hadersdorfer, Julia, Steffens, Thomas, Weisz, Nathan, Landgrebe, Michael, Hajak, Göran, Greenlee, Mark, Classen, Joseph, Langguth, Berthold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206892/
https://www.ncbi.nlm.nih.gov/pubmed/22073259
http://dx.doi.org/10.1371/journal.pone.0027088
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author Schecklmann, Martin
Volberg, Gregor
Frank, Gabriele
Hadersdorfer, Julia
Steffens, Thomas
Weisz, Nathan
Landgrebe, Michael
Hajak, Göran
Greenlee, Mark
Classen, Joseph
Langguth, Berthold
author_facet Schecklmann, Martin
Volberg, Gregor
Frank, Gabriele
Hadersdorfer, Julia
Steffens, Thomas
Weisz, Nathan
Landgrebe, Michael
Hajak, Göran
Greenlee, Mark
Classen, Joseph
Langguth, Berthold
author_sort Schecklmann, Martin
collection PubMed
description BACKGROUND: Paired associative stimulation (PAS) consisting of repeated application of transcranial magnetic stimulation (TMS) pulses and contingent exteroceptive stimuli has been shown to induce neuroplastic effects in the motor and somatosensory system. The objective was to investigate whether the auditory system can be modulated by PAS. METHODS: Acoustic stimuli (4 kHz) were paired with TMS of the auditory cortex with intervals of either 45 ms (PAS(45 ms)) or 10 ms (PAS(10 ms)). Two-hundred paired stimuli were applied at 0.1 Hz and effects were compared with low frequency repetitive TMS (rTMS) at 0.1 Hz (200 stimuli) and 1 Hz (1000 stimuli) in eleven healthy students. Auditory cortex excitability was measured before and after the interventions by long latency auditory evoked potentials (AEPs) for the tone (4 kHz) used in the pairing, and a control tone (1 kHz) in a within subjects design. RESULTS: Amplitudes of the N1-P2 complex were reduced for the 4 kHz tone after both PAS(45 ms) and PAS(10 ms), but not after the 0.1 Hz and 1 Hz rTMS protocols with more pronounced effects for PAS(45 ms). Similar, but less pronounced effects were observed for the 1 kHz control tone. CONCLUSION: These findings indicate that paired associative stimulation may induce tonotopically specific and also tone unspecific human auditory cortex plasticity.
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spelling pubmed-32068922011-11-09 Paired Associative Stimulation of the Auditory System: A Proof-Of-Principle Study Schecklmann, Martin Volberg, Gregor Frank, Gabriele Hadersdorfer, Julia Steffens, Thomas Weisz, Nathan Landgrebe, Michael Hajak, Göran Greenlee, Mark Classen, Joseph Langguth, Berthold PLoS One Research Article BACKGROUND: Paired associative stimulation (PAS) consisting of repeated application of transcranial magnetic stimulation (TMS) pulses and contingent exteroceptive stimuli has been shown to induce neuroplastic effects in the motor and somatosensory system. The objective was to investigate whether the auditory system can be modulated by PAS. METHODS: Acoustic stimuli (4 kHz) were paired with TMS of the auditory cortex with intervals of either 45 ms (PAS(45 ms)) or 10 ms (PAS(10 ms)). Two-hundred paired stimuli were applied at 0.1 Hz and effects were compared with low frequency repetitive TMS (rTMS) at 0.1 Hz (200 stimuli) and 1 Hz (1000 stimuli) in eleven healthy students. Auditory cortex excitability was measured before and after the interventions by long latency auditory evoked potentials (AEPs) for the tone (4 kHz) used in the pairing, and a control tone (1 kHz) in a within subjects design. RESULTS: Amplitudes of the N1-P2 complex were reduced for the 4 kHz tone after both PAS(45 ms) and PAS(10 ms), but not after the 0.1 Hz and 1 Hz rTMS protocols with more pronounced effects for PAS(45 ms). Similar, but less pronounced effects were observed for the 1 kHz control tone. CONCLUSION: These findings indicate that paired associative stimulation may induce tonotopically specific and also tone unspecific human auditory cortex plasticity. Public Library of Science 2011-11-02 /pmc/articles/PMC3206892/ /pubmed/22073259 http://dx.doi.org/10.1371/journal.pone.0027088 Text en Schecklmann et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Schecklmann, Martin
Volberg, Gregor
Frank, Gabriele
Hadersdorfer, Julia
Steffens, Thomas
Weisz, Nathan
Landgrebe, Michael
Hajak, Göran
Greenlee, Mark
Classen, Joseph
Langguth, Berthold
Paired Associative Stimulation of the Auditory System: A Proof-Of-Principle Study
title Paired Associative Stimulation of the Auditory System: A Proof-Of-Principle Study
title_full Paired Associative Stimulation of the Auditory System: A Proof-Of-Principle Study
title_fullStr Paired Associative Stimulation of the Auditory System: A Proof-Of-Principle Study
title_full_unstemmed Paired Associative Stimulation of the Auditory System: A Proof-Of-Principle Study
title_short Paired Associative Stimulation of the Auditory System: A Proof-Of-Principle Study
title_sort paired associative stimulation of the auditory system: a proof-of-principle study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206892/
https://www.ncbi.nlm.nih.gov/pubmed/22073259
http://dx.doi.org/10.1371/journal.pone.0027088
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