Inhibition of Striatal Soluble Guanylyl Cyclase-cGMP Signaling Reverses Basal Ganglia Dysfunction and Akinesia in Experimental Parkinsonism

OBJECTIVE: There is clearly a necessity to identify novel non-dopaminergic mechanisms as new therapeutic targets for Parkinson's disease (PD). Among these, the soluble guanylyl cyclase (sGC)-cGMP signaling cascade is emerging as a promising candidate for second messenger-based therapies for the...

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Detalles Bibliográficos
Autores principales: Tseng, Kuei Y., Caballero, Adriana, Dec, Alexander, Cass, Daryn K., Simak, Natalie, Sunu, Elizabeth, Park, Michael J., Blume, Shannon R., Sammut, Stephen, Park, Diana J., West, Anthony R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206945/
https://www.ncbi.nlm.nih.gov/pubmed/22073284
http://dx.doi.org/10.1371/journal.pone.0027187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206945/
https://www.ncbi.nlm.nih.gov/pubmed/22073284
http://dx.doi.org/10.1371/journal.pone.0027187

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