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TMEM106B a Novel Risk Factor for Frontotemporal Lobar Degeneration

Recently, the first genome-wide association (GWA) study in frontotemporal lobar degeneration (FTLD) identified common genetic variability at the TMEM106B gene on chromosome 7p21.3 as a potential important risk-modifying factor for FTLD with pathologic inclusions of TAR DNA-binding protein (FTLD-TDP)...

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Autores principales: van der Zee, Julie, Van Broeckhoven, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Humana Press Inc 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207134/
https://www.ncbi.nlm.nih.gov/pubmed/21614538
http://dx.doi.org/10.1007/s12031-011-9555-x
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author van der Zee, Julie
Van Broeckhoven, Christine
author_facet van der Zee, Julie
Van Broeckhoven, Christine
author_sort van der Zee, Julie
collection PubMed
description Recently, the first genome-wide association (GWA) study in frontotemporal lobar degeneration (FTLD) identified common genetic variability at the TMEM106B gene on chromosome 7p21.3 as a potential important risk-modifying factor for FTLD with pathologic inclusions of TAR DNA-binding protein (FTLD-TDP), the most common pathological subtype in FTLD. To gather additional evidence for the implication of TMEM106B in FTLD risk, multiple replication studies in geographically distinct populations were set up. In this review, we revise all recent replication and follow-up studies of the FTLD-TDP GWA study and summarize the growing body of evidence that establish TMEM106B as a bona fide risk factor for FTLD. With the TMEM106B gene, a new player has been identified in the pathogenic cascade of FTLD which could hold important implications for the future development of disease-modifying therapies.
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spelling pubmed-32071342011-11-28 TMEM106B a Novel Risk Factor for Frontotemporal Lobar Degeneration van der Zee, Julie Van Broeckhoven, Christine J Mol Neurosci Article Recently, the first genome-wide association (GWA) study in frontotemporal lobar degeneration (FTLD) identified common genetic variability at the TMEM106B gene on chromosome 7p21.3 as a potential important risk-modifying factor for FTLD with pathologic inclusions of TAR DNA-binding protein (FTLD-TDP), the most common pathological subtype in FTLD. To gather additional evidence for the implication of TMEM106B in FTLD risk, multiple replication studies in geographically distinct populations were set up. In this review, we revise all recent replication and follow-up studies of the FTLD-TDP GWA study and summarize the growing body of evidence that establish TMEM106B as a bona fide risk factor for FTLD. With the TMEM106B gene, a new player has been identified in the pathogenic cascade of FTLD which could hold important implications for the future development of disease-modifying therapies. Humana Press Inc 2011-05-26 2011 /pmc/articles/PMC3207134/ /pubmed/21614538 http://dx.doi.org/10.1007/s12031-011-9555-x Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
van der Zee, Julie
Van Broeckhoven, Christine
TMEM106B a Novel Risk Factor for Frontotemporal Lobar Degeneration
title TMEM106B a Novel Risk Factor for Frontotemporal Lobar Degeneration
title_full TMEM106B a Novel Risk Factor for Frontotemporal Lobar Degeneration
title_fullStr TMEM106B a Novel Risk Factor for Frontotemporal Lobar Degeneration
title_full_unstemmed TMEM106B a Novel Risk Factor for Frontotemporal Lobar Degeneration
title_short TMEM106B a Novel Risk Factor for Frontotemporal Lobar Degeneration
title_sort tmem106b a novel risk factor for frontotemporal lobar degeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207134/
https://www.ncbi.nlm.nih.gov/pubmed/21614538
http://dx.doi.org/10.1007/s12031-011-9555-x
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