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TMEM106B a Novel Risk Factor for Frontotemporal Lobar Degeneration
Recently, the first genome-wide association (GWA) study in frontotemporal lobar degeneration (FTLD) identified common genetic variability at the TMEM106B gene on chromosome 7p21.3 as a potential important risk-modifying factor for FTLD with pathologic inclusions of TAR DNA-binding protein (FTLD-TDP)...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Humana Press Inc
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207134/ https://www.ncbi.nlm.nih.gov/pubmed/21614538 http://dx.doi.org/10.1007/s12031-011-9555-x |
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author | van der Zee, Julie Van Broeckhoven, Christine |
author_facet | van der Zee, Julie Van Broeckhoven, Christine |
author_sort | van der Zee, Julie |
collection | PubMed |
description | Recently, the first genome-wide association (GWA) study in frontotemporal lobar degeneration (FTLD) identified common genetic variability at the TMEM106B gene on chromosome 7p21.3 as a potential important risk-modifying factor for FTLD with pathologic inclusions of TAR DNA-binding protein (FTLD-TDP), the most common pathological subtype in FTLD. To gather additional evidence for the implication of TMEM106B in FTLD risk, multiple replication studies in geographically distinct populations were set up. In this review, we revise all recent replication and follow-up studies of the FTLD-TDP GWA study and summarize the growing body of evidence that establish TMEM106B as a bona fide risk factor for FTLD. With the TMEM106B gene, a new player has been identified in the pathogenic cascade of FTLD which could hold important implications for the future development of disease-modifying therapies. |
format | Online Article Text |
id | pubmed-3207134 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Humana Press Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-32071342011-11-28 TMEM106B a Novel Risk Factor for Frontotemporal Lobar Degeneration van der Zee, Julie Van Broeckhoven, Christine J Mol Neurosci Article Recently, the first genome-wide association (GWA) study in frontotemporal lobar degeneration (FTLD) identified common genetic variability at the TMEM106B gene on chromosome 7p21.3 as a potential important risk-modifying factor for FTLD with pathologic inclusions of TAR DNA-binding protein (FTLD-TDP), the most common pathological subtype in FTLD. To gather additional evidence for the implication of TMEM106B in FTLD risk, multiple replication studies in geographically distinct populations were set up. In this review, we revise all recent replication and follow-up studies of the FTLD-TDP GWA study and summarize the growing body of evidence that establish TMEM106B as a bona fide risk factor for FTLD. With the TMEM106B gene, a new player has been identified in the pathogenic cascade of FTLD which could hold important implications for the future development of disease-modifying therapies. Humana Press Inc 2011-05-26 2011 /pmc/articles/PMC3207134/ /pubmed/21614538 http://dx.doi.org/10.1007/s12031-011-9555-x Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Article van der Zee, Julie Van Broeckhoven, Christine TMEM106B a Novel Risk Factor for Frontotemporal Lobar Degeneration |
title | TMEM106B a Novel Risk Factor for Frontotemporal Lobar Degeneration |
title_full | TMEM106B a Novel Risk Factor for Frontotemporal Lobar Degeneration |
title_fullStr | TMEM106B a Novel Risk Factor for Frontotemporal Lobar Degeneration |
title_full_unstemmed | TMEM106B a Novel Risk Factor for Frontotemporal Lobar Degeneration |
title_short | TMEM106B a Novel Risk Factor for Frontotemporal Lobar Degeneration |
title_sort | tmem106b a novel risk factor for frontotemporal lobar degeneration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207134/ https://www.ncbi.nlm.nih.gov/pubmed/21614538 http://dx.doi.org/10.1007/s12031-011-9555-x |
work_keys_str_mv | AT vanderzeejulie tmem106banovelriskfactorforfrontotemporallobardegeneration AT vanbroeckhovenchristine tmem106banovelriskfactorforfrontotemporallobardegeneration |