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Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia

Hepatocellular Carcinoma (HCC) is a leading cause of cancer-related death worldwide. Globally, the most important HCC risk factors are Hepatitis B Virus (HBV) and/or Hepatitis C Virus (HCV), chronic alcoholism, and dietary exposure to aflatoxins. We have described the epidemiological pattern of 202...

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Autores principales: Navas, Maria-Cristina, Suarez, Iris, Carreño, Andrea, Uribe, Diego, Rios, Wilson Alfredo, Cortes-Mancera, Fabian, Martel, Ghyslaine, Vieco, Beatriz, Lozano, Diana, Jimenez, Carlos, Gouas, Doriane, Osorio, German, Hoyos, Sergio, Restrepo, Juan Carlos, Correa, Gonzalo, Jaramillo, Sergio, Lopez, Rocio, Bravo, Luis Eduardo, Arbelaez, Maria Patricia, Scoazec, Jean-Yves, Abedi-Ardekani, Behnoush, Santella, Regina M., Chemin, Isabelle, Hainaut, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207138/
https://www.ncbi.nlm.nih.gov/pubmed/22114738
http://dx.doi.org/10.1155/2011/582945
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author Navas, Maria-Cristina
Suarez, Iris
Carreño, Andrea
Uribe, Diego
Rios, Wilson Alfredo
Cortes-Mancera, Fabian
Martel, Ghyslaine
Vieco, Beatriz
Lozano, Diana
Jimenez, Carlos
Gouas, Doriane
Osorio, German
Hoyos, Sergio
Restrepo, Juan Carlos
Correa, Gonzalo
Jaramillo, Sergio
Lopez, Rocio
Bravo, Luis Eduardo
Arbelaez, Maria Patricia
Scoazec, Jean-Yves
Abedi-Ardekani, Behnoush
Santella, Regina M.
Chemin, Isabelle
Hainaut, Pierre
author_facet Navas, Maria-Cristina
Suarez, Iris
Carreño, Andrea
Uribe, Diego
Rios, Wilson Alfredo
Cortes-Mancera, Fabian
Martel, Ghyslaine
Vieco, Beatriz
Lozano, Diana
Jimenez, Carlos
Gouas, Doriane
Osorio, German
Hoyos, Sergio
Restrepo, Juan Carlos
Correa, Gonzalo
Jaramillo, Sergio
Lopez, Rocio
Bravo, Luis Eduardo
Arbelaez, Maria Patricia
Scoazec, Jean-Yves
Abedi-Ardekani, Behnoush
Santella, Regina M.
Chemin, Isabelle
Hainaut, Pierre
author_sort Navas, Maria-Cristina
collection PubMed
description Hepatocellular Carcinoma (HCC) is a leading cause of cancer-related death worldwide. Globally, the most important HCC risk factors are Hepatitis B Virus (HBV) and/or Hepatitis C Virus (HCV), chronic alcoholism, and dietary exposure to aflatoxins. We have described the epidemiological pattern of 202 HCC samples obtained from Colombian patients. Additionally we investigated HBV/HCV infections and TP53 mutations in 49 of these HCC cases. HBV biomarkers were detected in 58.1% of the cases; HBV genotypes F and D were characterized in three of the samples. The HCV biomarker was detected in 37% of the samples while HBV/HCV coinfection was found in 19.2%. Among TP53 mutations, 10.5% occur at the common aflatoxin mutation hotspot, codon 249. No data regarding chronic alcoholism was available from the cases. In conclusion, in this first study of HCC and biomarkers in a Colombian population, the main HCC risk factor was HBV infection.
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spelling pubmed-32071382011-11-23 Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia Navas, Maria-Cristina Suarez, Iris Carreño, Andrea Uribe, Diego Rios, Wilson Alfredo Cortes-Mancera, Fabian Martel, Ghyslaine Vieco, Beatriz Lozano, Diana Jimenez, Carlos Gouas, Doriane Osorio, German Hoyos, Sergio Restrepo, Juan Carlos Correa, Gonzalo Jaramillo, Sergio Lopez, Rocio Bravo, Luis Eduardo Arbelaez, Maria Patricia Scoazec, Jean-Yves Abedi-Ardekani, Behnoush Santella, Regina M. Chemin, Isabelle Hainaut, Pierre Hepat Res Treat Research Article Hepatocellular Carcinoma (HCC) is a leading cause of cancer-related death worldwide. Globally, the most important HCC risk factors are Hepatitis B Virus (HBV) and/or Hepatitis C Virus (HCV), chronic alcoholism, and dietary exposure to aflatoxins. We have described the epidemiological pattern of 202 HCC samples obtained from Colombian patients. Additionally we investigated HBV/HCV infections and TP53 mutations in 49 of these HCC cases. HBV biomarkers were detected in 58.1% of the cases; HBV genotypes F and D were characterized in three of the samples. The HCV biomarker was detected in 37% of the samples while HBV/HCV coinfection was found in 19.2%. Among TP53 mutations, 10.5% occur at the common aflatoxin mutation hotspot, codon 249. No data regarding chronic alcoholism was available from the cases. In conclusion, in this first study of HCC and biomarkers in a Colombian population, the main HCC risk factor was HBV infection. Hindawi Publishing Corporation 2011 2011-10-31 /pmc/articles/PMC3207138/ /pubmed/22114738 http://dx.doi.org/10.1155/2011/582945 Text en Copyright © 2011 Maria-Cristina Navas et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Navas, Maria-Cristina
Suarez, Iris
Carreño, Andrea
Uribe, Diego
Rios, Wilson Alfredo
Cortes-Mancera, Fabian
Martel, Ghyslaine
Vieco, Beatriz
Lozano, Diana
Jimenez, Carlos
Gouas, Doriane
Osorio, German
Hoyos, Sergio
Restrepo, Juan Carlos
Correa, Gonzalo
Jaramillo, Sergio
Lopez, Rocio
Bravo, Luis Eduardo
Arbelaez, Maria Patricia
Scoazec, Jean-Yves
Abedi-Ardekani, Behnoush
Santella, Regina M.
Chemin, Isabelle
Hainaut, Pierre
Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia
title Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia
title_full Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia
title_fullStr Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia
title_full_unstemmed Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia
title_short Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia
title_sort hepatitis b and hepatitis c infection biomarkers and tp53 mutations in hepatocellular carcinomas from colombia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207138/
https://www.ncbi.nlm.nih.gov/pubmed/22114738
http://dx.doi.org/10.1155/2011/582945
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