Enhancing the Clinical Potential of AAV Vectors by Capsid Engineering to Evade Pre-Existing Immunity

Vectors based on adeno-associated viruses (AAV) have shown considerable promise in both preclinical models and increasingly in clinical trials. However, one formidable challenge is pre-existing immunity due to widespread exposure to numerous AAV variants and serotypes within the human population, wh...

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Detalles Bibliográficos
Autores principales: Bartel, Melissa, Schaffer, David, Büning, Hildegard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207363/
https://www.ncbi.nlm.nih.gov/pubmed/22065962
http://dx.doi.org/10.3389/fmicb.2011.00204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207363/
https://www.ncbi.nlm.nih.gov/pubmed/22065962
http://dx.doi.org/10.3389/fmicb.2011.00204

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