Association of Genetic Loci with Blood Lipids in the Chinese Population

BACKGROUND: Recent genome-wide association (GWA) studies have identified a number of novel genetic determinants of blood lipid concentrations in Europeans. However, it is still unclear whether these loci identified in the Caucasian GWA studies also exert the same effect on lipid concentrations in th...

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Autores principales: Zhang, Zhou, Tao, Liming, Chen, Zhuo, Zhou, Daizhan, Kan, Mengyuan, Zhang, Di, Li, Can, He, Lin, Liu, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207848/
https://www.ncbi.nlm.nih.gov/pubmed/22073310
http://dx.doi.org/10.1371/journal.pone.0027305
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author Zhang, Zhou
Tao, Liming
Chen, Zhuo
Zhou, Daizhan
Kan, Mengyuan
Zhang, Di
Li, Can
He, Lin
Liu, Yun
author_facet Zhang, Zhou
Tao, Liming
Chen, Zhuo
Zhou, Daizhan
Kan, Mengyuan
Zhang, Di
Li, Can
He, Lin
Liu, Yun
author_sort Zhang, Zhou
collection PubMed
description BACKGROUND: Recent genome-wide association (GWA) studies have identified a number of novel genetic determinants of blood lipid concentrations in Europeans. However, it is still unclear whether these loci identified in the Caucasian GWA studies also exert the same effect on lipid concentrations in the Chinese population. METHODS AND RESULTS: We conducted a replication study assessing associations between SNPs at 15 loci and blood lipid and lipoprotein concentrations in two Chinese cohorts, comprising 2533 and 2105 individuals respectively. SNPs in APO(A1/C3/A4/A5), TIMD4-HAVCR1, DOCK7, TRIB1, ABCA1, and TOMM40-APOE showed strong associations with at least one lipids trait, and rs174546 in FADS1/2/3 showed modest association with triglyceride in the Chinese population. CONCLUSIONS: We successfully replicated 7 loci associated plasma lipid concentrations in the Chinese population. Our study confirmed the implication of APO(A1/C3/A4/A5), TOMM40-APOE, ABCA1, DOCK7, TIMD4-HAVCR1, TRIB1 and FADS1/2 in plasma lipid and lipoprotein concentrations in Chinese population.
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spelling pubmed-32078482011-11-09 Association of Genetic Loci with Blood Lipids in the Chinese Population Zhang, Zhou Tao, Liming Chen, Zhuo Zhou, Daizhan Kan, Mengyuan Zhang, Di Li, Can He, Lin Liu, Yun PLoS One Research Article BACKGROUND: Recent genome-wide association (GWA) studies have identified a number of novel genetic determinants of blood lipid concentrations in Europeans. However, it is still unclear whether these loci identified in the Caucasian GWA studies also exert the same effect on lipid concentrations in the Chinese population. METHODS AND RESULTS: We conducted a replication study assessing associations between SNPs at 15 loci and blood lipid and lipoprotein concentrations in two Chinese cohorts, comprising 2533 and 2105 individuals respectively. SNPs in APO(A1/C3/A4/A5), TIMD4-HAVCR1, DOCK7, TRIB1, ABCA1, and TOMM40-APOE showed strong associations with at least one lipids trait, and rs174546 in FADS1/2/3 showed modest association with triglyceride in the Chinese population. CONCLUSIONS: We successfully replicated 7 loci associated plasma lipid concentrations in the Chinese population. Our study confirmed the implication of APO(A1/C3/A4/A5), TOMM40-APOE, ABCA1, DOCK7, TIMD4-HAVCR1, TRIB1 and FADS1/2 in plasma lipid and lipoprotein concentrations in Chinese population. Public Library of Science 2011-11-03 /pmc/articles/PMC3207848/ /pubmed/22073310 http://dx.doi.org/10.1371/journal.pone.0027305 Text en Zhang et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Zhang, Zhou
Tao, Liming
Chen, Zhuo
Zhou, Daizhan
Kan, Mengyuan
Zhang, Di
Li, Can
He, Lin
Liu, Yun
Association of Genetic Loci with Blood Lipids in the Chinese Population
title Association of Genetic Loci with Blood Lipids in the Chinese Population
title_full Association of Genetic Loci with Blood Lipids in the Chinese Population
title_fullStr Association of Genetic Loci with Blood Lipids in the Chinese Population
title_full_unstemmed Association of Genetic Loci with Blood Lipids in the Chinese Population
title_short Association of Genetic Loci with Blood Lipids in the Chinese Population
title_sort association of genetic loci with blood lipids in the chinese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207848/
https://www.ncbi.nlm.nih.gov/pubmed/22073310
http://dx.doi.org/10.1371/journal.pone.0027305
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