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Red blood cell transfusion in the critically ill patient
Red blood cell (RBC) transfusion is a common intervention in intensive care unit (ICU) patients. Anemia is frequent in this population and is associated with poor outcomes, especially in patients with ischemic heart disease. Although blood transfusions are generally given to improve tissue oxygenati...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207872/ https://www.ncbi.nlm.nih.gov/pubmed/21970512 http://dx.doi.org/10.1186/2110-5820-1-43 |
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author | Lelubre, Christophe Vincent, Jean-Louis |
author_facet | Lelubre, Christophe Vincent, Jean-Louis |
author_sort | Lelubre, Christophe |
collection | PubMed |
description | Red blood cell (RBC) transfusion is a common intervention in intensive care unit (ICU) patients. Anemia is frequent in this population and is associated with poor outcomes, especially in patients with ischemic heart disease. Although blood transfusions are generally given to improve tissue oxygenation, they do not systematically increase oxygen consumption and effects on oxygen delivery are not always very impressive. Blood transfusion may be lifesaving in some circumstances, but many studies have reported increased morbidity and mortality in transfused patients. This review focuses on some important aspects of RBC transfusion in the ICU, including physiologic considerations, a brief description of serious infectious and noninfectious hazards of transfusion, and the effects of RBC storage lesions. Emphasis is placed on the importance of personalizing blood transfusion according to physiological endpoints rather than arbitrary thresholds. |
format | Online Article Text |
id | pubmed-3207872 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Springer |
record_format | MEDLINE/PubMed |
spelling | pubmed-32078722011-12-16 Red blood cell transfusion in the critically ill patient Lelubre, Christophe Vincent, Jean-Louis Ann Intensive Care Review Red blood cell (RBC) transfusion is a common intervention in intensive care unit (ICU) patients. Anemia is frequent in this population and is associated with poor outcomes, especially in patients with ischemic heart disease. Although blood transfusions are generally given to improve tissue oxygenation, they do not systematically increase oxygen consumption and effects on oxygen delivery are not always very impressive. Blood transfusion may be lifesaving in some circumstances, but many studies have reported increased morbidity and mortality in transfused patients. This review focuses on some important aspects of RBC transfusion in the ICU, including physiologic considerations, a brief description of serious infectious and noninfectious hazards of transfusion, and the effects of RBC storage lesions. Emphasis is placed on the importance of personalizing blood transfusion according to physiological endpoints rather than arbitrary thresholds. Springer 2011-10-04 /pmc/articles/PMC3207872/ /pubmed/21970512 http://dx.doi.org/10.1186/2110-5820-1-43 Text en Copyright ©2011 Lelubre and Vincent; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Lelubre, Christophe Vincent, Jean-Louis Red blood cell transfusion in the critically ill patient |
title | Red blood cell transfusion in the critically ill patient |
title_full | Red blood cell transfusion in the critically ill patient |
title_fullStr | Red blood cell transfusion in the critically ill patient |
title_full_unstemmed | Red blood cell transfusion in the critically ill patient |
title_short | Red blood cell transfusion in the critically ill patient |
title_sort | red blood cell transfusion in the critically ill patient |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207872/ https://www.ncbi.nlm.nih.gov/pubmed/21970512 http://dx.doi.org/10.1186/2110-5820-1-43 |
work_keys_str_mv | AT lelubrechristophe redbloodcelltransfusioninthecriticallyillpatient AT vincentjeanlouis redbloodcelltransfusioninthecriticallyillpatient |