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Cattle remain immunocompetent during the acute phase of foot-and-mouth disease virus infection

Infection of cattle with foot-and-mouth disease virus (FMDV) results in the development of long-term protective antibody responses. In contrast, inactivated antigen vaccines fail to induce long-term protective immunity. Differences between susceptible species have also been observed during infection...

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Autores principales: Windsor, Miriam A, Carr, B Veronica, Bankowski, Bartomiej, Gibson, Debi, Reid, Elizabeth, Hamblin, Pip, Gubbins, Simon, Juleff, Nicholas, Charleston, Bryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207891/
https://www.ncbi.nlm.nih.gov/pubmed/22014145
http://dx.doi.org/10.1186/1297-9716-42-108
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author Windsor, Miriam A
Carr, B Veronica
Bankowski, Bartomiej
Gibson, Debi
Reid, Elizabeth
Hamblin, Pip
Gubbins, Simon
Juleff, Nicholas
Charleston, Bryan
author_facet Windsor, Miriam A
Carr, B Veronica
Bankowski, Bartomiej
Gibson, Debi
Reid, Elizabeth
Hamblin, Pip
Gubbins, Simon
Juleff, Nicholas
Charleston, Bryan
author_sort Windsor, Miriam A
collection PubMed
description Infection of cattle with foot-and-mouth disease virus (FMDV) results in the development of long-term protective antibody responses. In contrast, inactivated antigen vaccines fail to induce long-term protective immunity. Differences between susceptible species have also been observed during infection with FMDV, with cattle often developing persistent infections whilst pigs develop more severe symptoms and excrete higher levels of virus. This study examined the early immune response to FMDV in naïve cattle after in-contact challenge. Cattle exposed to FMDV were found to be viraemic and produced neutralising antibody, consistent with previous reports. In contrast to previous studies in pigs these cattle did not develop leucopenia, and the proliferative responses of peripheral blood mononuclear cells to either mitogen or third party antigen were not suppressed. Low levels of type 1 interferon and IL-10 were detected in the circulation. Taken together, these results suggest that there was no generalised immunosuppression during the acute phase of FMDV infection in cattle.
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spelling pubmed-32078912011-11-04 Cattle remain immunocompetent during the acute phase of foot-and-mouth disease virus infection Windsor, Miriam A Carr, B Veronica Bankowski, Bartomiej Gibson, Debi Reid, Elizabeth Hamblin, Pip Gubbins, Simon Juleff, Nicholas Charleston, Bryan Vet Res Research Infection of cattle with foot-and-mouth disease virus (FMDV) results in the development of long-term protective antibody responses. In contrast, inactivated antigen vaccines fail to induce long-term protective immunity. Differences between susceptible species have also been observed during infection with FMDV, with cattle often developing persistent infections whilst pigs develop more severe symptoms and excrete higher levels of virus. This study examined the early immune response to FMDV in naïve cattle after in-contact challenge. Cattle exposed to FMDV were found to be viraemic and produced neutralising antibody, consistent with previous reports. In contrast to previous studies in pigs these cattle did not develop leucopenia, and the proliferative responses of peripheral blood mononuclear cells to either mitogen or third party antigen were not suppressed. Low levels of type 1 interferon and IL-10 were detected in the circulation. Taken together, these results suggest that there was no generalised immunosuppression during the acute phase of FMDV infection in cattle. BioMed Central 2011 2011-10-20 /pmc/articles/PMC3207891/ /pubmed/22014145 http://dx.doi.org/10.1186/1297-9716-42-108 Text en Copyright ©2011 Windsor et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Windsor, Miriam A
Carr, B Veronica
Bankowski, Bartomiej
Gibson, Debi
Reid, Elizabeth
Hamblin, Pip
Gubbins, Simon
Juleff, Nicholas
Charleston, Bryan
Cattle remain immunocompetent during the acute phase of foot-and-mouth disease virus infection
title Cattle remain immunocompetent during the acute phase of foot-and-mouth disease virus infection
title_full Cattle remain immunocompetent during the acute phase of foot-and-mouth disease virus infection
title_fullStr Cattle remain immunocompetent during the acute phase of foot-and-mouth disease virus infection
title_full_unstemmed Cattle remain immunocompetent during the acute phase of foot-and-mouth disease virus infection
title_short Cattle remain immunocompetent during the acute phase of foot-and-mouth disease virus infection
title_sort cattle remain immunocompetent during the acute phase of foot-and-mouth disease virus infection
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207891/
https://www.ncbi.nlm.nih.gov/pubmed/22014145
http://dx.doi.org/10.1186/1297-9716-42-108
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