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Activation of Bmp2-Smad1 Signal and Its Regulation by Coordinated Alteration of H3K27 Trimethylation in Ras-Induced Senescence

Cellular senescence involves epigenetic alteration, e.g. loss of H3K27me3 in Ink4a-Arf locus. Using mouse embryonic fibroblast (MEF), we here analyzed transcription and epigenetic alteration during Ras-induced senescence on genome-wide scale by chromatin immunoprecipitation (ChIP)-sequencing and mic...

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Detalles Bibliográficos
Autores principales:	Kaneda, Atsushi, Fujita, Takanori, Anai, Motonobu, Yamamoto, Shogo, Nagae, Genta, Morikawa, Masato, Tsuji, Shingo, Oshima, Masanobu, Miyazono, Kohei, Aburatani, Hiroyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207904/ https://www.ncbi.nlm.nih.gov/pubmed/22072987 http://dx.doi.org/10.1371/journal.pgen.1002359

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