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Bone quality and growth characteristics of growth plates following limb transplantation between animals of different ages - Results of an experimental study in male syngeneic rats
INTRODUCTION: The purpose of this study was to identify graft osteoporosis post transplantation by micro-CT analysis, and the growth potential of growth plates in the transplanted limb. METHODS: Ten juvenile to juvenile and five juvenile to adult hind limb transplants were performed in male syngenei...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207911/ https://www.ncbi.nlm.nih.gov/pubmed/21999811 http://dx.doi.org/10.1186/1749-799X-6-53 |
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author | Modi, Hitesh N Suh, Seung Woo Prjvc, Boopalan Hong, Jae-Young Yang, Jae-Hyuk Park, Young-Hwan Lee, Jae-Moon Kwon, Yong-Hyon |
author_facet | Modi, Hitesh N Suh, Seung Woo Prjvc, Boopalan Hong, Jae-Young Yang, Jae-Hyuk Park, Young-Hwan Lee, Jae-Moon Kwon, Yong-Hyon |
author_sort | Modi, Hitesh N |
collection | PubMed |
description | INTRODUCTION: The purpose of this study was to identify graft osteoporosis post transplantation by micro-CT analysis, and the growth potential of growth plates in the transplanted limb. METHODS: Ten juvenile to juvenile and five juvenile to adult hind limb transplants were performed in male syngeneic Lewis rats. Upper tibial bone density in isochronograft and heterochronograft limbs was measured by 3D micro-CT and compared with that of the opposite non-operated limbs. RESULTS: We observed inferior bone quality (p < 0.05) in heterochronografts compared to isochronografts. After transplantation, isochronografts did not exhibit increases in tibial lengths compared to opposite juvenile non-operated tibias (p = 0.66) or heterochronograft tibias (p = 0.61). However, significant differences were observed between heterochrongraft tibial lengths when and opposite adult non operated tibial lengths (p < 0.001). CONCLUSIONS: Age dependent alterations affect bone quality, resulting in post transplantation osteoporosis in heterochronografts, but not isochronografts. However, the growth plates of transplanted limbs retain their properties of longitudinal growth and continue to grow at the same rate. |
format | Online Article Text |
id | pubmed-3207911 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32079112011-11-04 Bone quality and growth characteristics of growth plates following limb transplantation between animals of different ages - Results of an experimental study in male syngeneic rats Modi, Hitesh N Suh, Seung Woo Prjvc, Boopalan Hong, Jae-Young Yang, Jae-Hyuk Park, Young-Hwan Lee, Jae-Moon Kwon, Yong-Hyon J Orthop Surg Res Research Article INTRODUCTION: The purpose of this study was to identify graft osteoporosis post transplantation by micro-CT analysis, and the growth potential of growth plates in the transplanted limb. METHODS: Ten juvenile to juvenile and five juvenile to adult hind limb transplants were performed in male syngeneic Lewis rats. Upper tibial bone density in isochronograft and heterochronograft limbs was measured by 3D micro-CT and compared with that of the opposite non-operated limbs. RESULTS: We observed inferior bone quality (p < 0.05) in heterochronografts compared to isochronografts. After transplantation, isochronografts did not exhibit increases in tibial lengths compared to opposite juvenile non-operated tibias (p = 0.66) or heterochronograft tibias (p = 0.61). However, significant differences were observed between heterochrongraft tibial lengths when and opposite adult non operated tibial lengths (p < 0.001). CONCLUSIONS: Age dependent alterations affect bone quality, resulting in post transplantation osteoporosis in heterochronografts, but not isochronografts. However, the growth plates of transplanted limbs retain their properties of longitudinal growth and continue to grow at the same rate. BioMed Central 2011-10-14 /pmc/articles/PMC3207911/ /pubmed/21999811 http://dx.doi.org/10.1186/1749-799X-6-53 Text en Copyright ©2011 Modi et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Modi, Hitesh N Suh, Seung Woo Prjvc, Boopalan Hong, Jae-Young Yang, Jae-Hyuk Park, Young-Hwan Lee, Jae-Moon Kwon, Yong-Hyon Bone quality and growth characteristics of growth plates following limb transplantation between animals of different ages - Results of an experimental study in male syngeneic rats |
title | Bone quality and growth characteristics of growth plates following limb transplantation between animals of different ages - Results of an experimental study in male syngeneic rats |
title_full | Bone quality and growth characteristics of growth plates following limb transplantation between animals of different ages - Results of an experimental study in male syngeneic rats |
title_fullStr | Bone quality and growth characteristics of growth plates following limb transplantation between animals of different ages - Results of an experimental study in male syngeneic rats |
title_full_unstemmed | Bone quality and growth characteristics of growth plates following limb transplantation between animals of different ages - Results of an experimental study in male syngeneic rats |
title_short | Bone quality and growth characteristics of growth plates following limb transplantation between animals of different ages - Results of an experimental study in male syngeneic rats |
title_sort | bone quality and growth characteristics of growth plates following limb transplantation between animals of different ages - results of an experimental study in male syngeneic rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207911/ https://www.ncbi.nlm.nih.gov/pubmed/21999811 http://dx.doi.org/10.1186/1749-799X-6-53 |
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