Cargando…

Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses

BACKGROUND: The PHArmacogenetic study of Statins in the Elderly at risk (PHASE) is a genome wide association study in the PROspective Study of Pravastatin in the Elderly at risk for vascular disease (PROSPER) that investigates the genetic variation responsible for the individual variation in drug re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Trompet, Stella, de Craen, Anton JM, Postmus, Iris, Ford, Ian, Sattar, Naveed, Caslake, Muriel, Stott, David J, Buckley, Brendan M, Sacks, Frank, Devlin, James J, Slagboom, P Eline, Westendorp, Rudi GJ, Jukema, J Wouter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207930/ https://www.ncbi.nlm.nih.gov/pubmed/21977987 http://dx.doi.org/10.1186/1471-2350-12-131

Ejemplares similares

C-Reactive Protein and Genetic Variants and Cognitive Decline in Old Age: The PROSPER Study
por: Mooijaart, Simon P., et al.
Publicado: (2011)

Long-Term Effects of Statin Treatment in Elderly People: Extended Follow-Up of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER)
por: Lloyd, Suzanne M., et al.
Publicado: (2013)

Blood Pressure Variability and Cardiovascular Risk in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER)
por: Poortvliet, Rosalinde K. E., et al.
Publicado: (2012)

Incident venous thromboembolic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)
por: Freeman, Dilys J, et al.
Publicado: (2011)

Non-response to (statin) therapy: the importance of distinguishing non-responders from non-adherers in pharmacogenetic studies
por: Trompet, S., et al.
Publicado: (2015)

Genome-Wide Study of Gene Variants Associated with Differential Cardiovascular Event Reduction by Pravastatin Therapy
por: Shiffman, Dov, et al.
Publicado: (2012)

A Prospective Study of Pravastatin in the Elderly at Risk (PROSPER): Screening Experience and Baseline Characteristics
por: Ford, Ian, et al.
Publicado: (2002)

A Prospective Analysis of Elevated Fasting Glucose Levels and Cognitive Function in Older People: Results From PROSPER and the Rotterdam Study
por: Euser, Sjoerd M., et al.
Publicado: (2010)

Subclinical Thyroid Dysfunction and Cognitive Decline in Old Age
por: Wijsman, Liselotte W., et al.
Publicado: (2013)

Systematic Testing of Literature Reported Genetic Variation Associated with Coronary Restenosis: Results of the GENDER Study
por: Verschuren, Jeffrey J. W., et al.
Publicado: (2012)

Leptin Predicts Diabetes but Not Cardiovascular Disease: Results from a large prospective study in an elderly population
por: Welsh, Paul, et al.
Publicado: (2009)

Handgrip strength at midlife and familial longevity: The Leiden Longevity Study
por: Ling, Carolina H. Y., et al.
Publicado: (2011)

Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study
por: van der Spoel, Evie, et al.
Publicado: (2015)

Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study
por: Mooijaart, Simon P., et al.
Publicado: (2010)

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways
por: Deelen, Joris, et al.
Publicado: (2011)

Reduced Glomerular Filtration Rate and Its Association with Clinical Outcome in Older Patients at Risk of Vascular Events: Secondary Analysis
por: Ford, Ian, et al.
Publicado: (2009)

Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality
por: Trompet, Stella, et al.
Publicado: (2011)

Endothelium-Dependent NO-Mediated Vasodilation in Humans is Attenuated by Peripheral α(1)-Adrenoceptor Activation
por: Kamper, Adriaan M, et al.
Publicado: (2005)

The Future Is Prosperous
por: de Koning, Harry J
Publicado: (2019)

Non-Homologous End-Joining Pathway Associated with Occurrence of Myocardial Infarction: Gene Set Analysis of Genome-Wide Association Study Data
por: Verschuren, Jeffrey J. W., et al.
Publicado: (2013)

Functional validation of GWAS hits for liver disease
Publicado: (2013)

Nuclear magnetic resonance‐based metabolomics identifies phenylalanine as a novel predictor of incident heart failure hospitalisation: results from PROSPER and FINRISK 1997
por: Delles, Christian, et al.
Publicado: (2017)

Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults
por: Chen, Sijia, et al.
Publicado: (2020)

Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people
por: Derhovanessian, Evelyna, et al.
Publicado: (2012)

CONQUER: an interactive toolbox to understand functional consequences of GWAS hits
por: Bouland, Gerard A, et al.
Publicado: (2020)

DNA damage markers in dermal fibroblasts in vitro reflect chronological donor age
por: Waaijer, Mariëtte E.C., et al.
Publicado: (2016)

An In Vivo Study on Brain Microstructure in Biological and Chronological Ageing
por: Altmann-Schneider, Irmhild, et al.
Publicado: (2015)

Prosperity and Cancer
Publicado: (1897)

The Wages of Prosperity
Publicado: (1900)

That Wave of Prosperity
Publicado: (1897)

The Journal’s Prosperity
Publicado: (1861)

Scarcity of atrial fibrillation in a traditional African population: a community-based study
por: Koopman, Jacob JE, et al.
Publicado: (2014)

Using genetic variation for establishing causality of cardiovascular risk factors: overcoming confounding and reverse causality
por: Smit, R. A. J., et al.
Publicado: (2014)

Human insulin/IGF-1 and familial longevity at middle age
por: Rozing, Maarten P., et al.
Publicado: (2009)

"Prosperity" : leyendas y verdades sobre la vida económica americana /
por: Bonn, Moritz J. 1873-1965 (Moritz Julius)
Publicado: (1931)

Homocysteine Levels and Treatment Effect in the Prospective Study of Pravastatin in the Elderly at Risk
por: Drewes, Yvonne M, et al.
Publicado: (2014)

Familial Longevity Is Marked by Better Cognitive Performance at Middle Age: The Leiden Longevity Study
por: Stijntjes, Marjon, et al.
Publicado: (2013)

Effects of a Web-Based Intervention on Physical Activity and Metabolism in Older Adults: Randomized Controlled Trial
por: Wijsman, Carolien A, et al.
Publicado: (2013)

The association of kidney function and cognitive decline in older patients at risk of cardiovascular disease: a longitudinal data analysis
por: Zijlstra, Laurien E., et al.
Publicado: (2020)

ApoE Plasma Levels and Risk of Cardiovascular Mortality in Old Age
por: Mooijaart, Simon P, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_seabhq31dk6r94qc88240eacgc