Fatal Prion Disease in a Mouse Model of Genetic E200K Creutzfeldt-Jakob Disease

Genetic prion diseases are late onset fatal neurodegenerative disorders linked to pathogenic mutations in the prion protein-encoding gene, PRNP. The most prevalent of these is the substitution of Glutamate for Lysine at codon 200 (E200K), causing genetic Creutzfeldt-Jakob disease (gCJD) in several c...

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Detalles Bibliográficos
Autores principales: Friedman-Levi, Yael, Meiner, Zeev, Canello, Tamar, Frid, Kati, Kovacs, Gabor G., Budka, Herbert, Avrahami, Dana, Gabizon, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207931/
https://www.ncbi.nlm.nih.gov/pubmed/22072968
http://dx.doi.org/10.1371/journal.ppat.1002350

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