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Estimated enterolignans, lignan-rich foods, and fibre in relation to survival after postmenopausal breast cancer

BACKGROUND: Lignans – oestrogenic substances present in various foods – are associated with postmenopausal breast cancer risk, but not much is known regarding their effects on survival. METHODS: In a follow-up study of 2653 postmenopausal breast cancer patients diagnosed between 2001 and 2005, vital...

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Autores principales: Buck, K, Zaineddin, A K, Vrieling, A, Heinz, J, Linseisen, J, Flesch-Janys, D, Chang-Claude, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208499/
https://www.ncbi.nlm.nih.gov/pubmed/21915130
http://dx.doi.org/10.1038/bjc.2011.374
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author Buck, K
Zaineddin, A K
Vrieling, A
Heinz, J
Linseisen, J
Flesch-Janys, D
Chang-Claude, J
author_facet Buck, K
Zaineddin, A K
Vrieling, A
Heinz, J
Linseisen, J
Flesch-Janys, D
Chang-Claude, J
author_sort Buck, K
collection PubMed
description BACKGROUND: Lignans – oestrogenic substances present in various foods – are associated with postmenopausal breast cancer risk, but not much is known regarding their effects on survival. METHODS: In a follow-up study of 2653 postmenopausal breast cancer patients diagnosed between 2001 and 2005, vital status and causes of death were verified through end of 2009. Hazard ratios (HRs) and 95% confidence intervals (CIs) for estimated enterolignans, lignan-rich foods, and dietary fibre in relation to overall survival (OS) and breast cancer-specific survival (BCSS) were assessed using Cox proportional hazards models stratified by age at diagnosis and adjusted for prognostic/confounding factors. RESULTS: Median follow-up time was 6.4 years, and 321 women died, 235 with breast cancer. High estimated enterolactone and enterodiol levels were associated with significantly lower overall mortality (highest quintile, HR=0.60, 95% CI=0.40–0.89, P(Trend)=0.02 and HR=0.63, 95% CI=0.42–0.95, P(Trend)=0.02, respectively). Fibre intake was also associated with a significantly lower overall mortality. Differentiated by median fibre intake, associations with estimated enterolignans were still evident at low but not high fibre intake. There was no effect modification by oestrogen receptor status and menopausal hormone therapy. CONCLUSION: Postmenopausal breast cancer patients with high estimated enterolignans may have a better survival.
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spelling pubmed-32084992012-10-11 Estimated enterolignans, lignan-rich foods, and fibre in relation to survival after postmenopausal breast cancer Buck, K Zaineddin, A K Vrieling, A Heinz, J Linseisen, J Flesch-Janys, D Chang-Claude, J Br J Cancer Clinical Study BACKGROUND: Lignans – oestrogenic substances present in various foods – are associated with postmenopausal breast cancer risk, but not much is known regarding their effects on survival. METHODS: In a follow-up study of 2653 postmenopausal breast cancer patients diagnosed between 2001 and 2005, vital status and causes of death were verified through end of 2009. Hazard ratios (HRs) and 95% confidence intervals (CIs) for estimated enterolignans, lignan-rich foods, and dietary fibre in relation to overall survival (OS) and breast cancer-specific survival (BCSS) were assessed using Cox proportional hazards models stratified by age at diagnosis and adjusted for prognostic/confounding factors. RESULTS: Median follow-up time was 6.4 years, and 321 women died, 235 with breast cancer. High estimated enterolactone and enterodiol levels were associated with significantly lower overall mortality (highest quintile, HR=0.60, 95% CI=0.40–0.89, P(Trend)=0.02 and HR=0.63, 95% CI=0.42–0.95, P(Trend)=0.02, respectively). Fibre intake was also associated with a significantly lower overall mortality. Differentiated by median fibre intake, associations with estimated enterolignans were still evident at low but not high fibre intake. There was no effect modification by oestrogen receptor status and menopausal hormone therapy. CONCLUSION: Postmenopausal breast cancer patients with high estimated enterolignans may have a better survival. Nature Publishing Group 2011-10-11 2011-09-13 /pmc/articles/PMC3208499/ /pubmed/21915130 http://dx.doi.org/10.1038/bjc.2011.374 Text en Copyright © 2011 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Clinical Study
Buck, K
Zaineddin, A K
Vrieling, A
Heinz, J
Linseisen, J
Flesch-Janys, D
Chang-Claude, J
Estimated enterolignans, lignan-rich foods, and fibre in relation to survival after postmenopausal breast cancer
title Estimated enterolignans, lignan-rich foods, and fibre in relation to survival after postmenopausal breast cancer
title_full Estimated enterolignans, lignan-rich foods, and fibre in relation to survival after postmenopausal breast cancer
title_fullStr Estimated enterolignans, lignan-rich foods, and fibre in relation to survival after postmenopausal breast cancer
title_full_unstemmed Estimated enterolignans, lignan-rich foods, and fibre in relation to survival after postmenopausal breast cancer
title_short Estimated enterolignans, lignan-rich foods, and fibre in relation to survival after postmenopausal breast cancer
title_sort estimated enterolignans, lignan-rich foods, and fibre in relation to survival after postmenopausal breast cancer
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208499/
https://www.ncbi.nlm.nih.gov/pubmed/21915130
http://dx.doi.org/10.1038/bjc.2011.374
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