Modeling the Mechanism of Action of a DGAT1 Inhibitor Using a Causal Reasoning Platform

Triglyceride accumulation is associated with obesity and type 2 diabetes. Genetic disruption of diacylglycerol acyltransferase 1 (DGAT1), which catalyzes the final reaction of triglyceride synthesis, confers dramatic resistance to high-fat diet induced obesity. Hence, DGAT1 is considered a potential...

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Detalles Bibliográficos
Autores principales: Enayetallah, Ahmed E., Ziemek, Daniel, Leininger, Michael T., Randhawa, Ranjit, Yang, Jianxin, Manion, Tara B., Mather, Dawn E., Zavadoski, William J., Kuhn, Max, Treadway, Judith L., des Etages, Shelly Ann G., Gibbs, E. Michael, Greene, Nigel, Steppan, Claire M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208573/
https://www.ncbi.nlm.nih.gov/pubmed/22073239
http://dx.doi.org/10.1371/journal.pone.0027009

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