Integrated Epigenetics of Human Breast Cancer: Synoptic Investigation of Targeted Genes, MicroRNAs and Proteins upon Demethylation Treatment

BACKGROUND: The contribution of aberrant DNA methylation in silencing of tumor suppressor genes (TSGs) and microRNAs has been investigated. Since these epigenetic alterations are reversible, it became of interest to determine the effects of the 5-aza-2′-deoxycytidine (DAC) demethylation therapy in b...

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Detalles Bibliográficos
Autores principales: Radpour, Ramin, Barekati, Zeinab, Kohler, Corina, Schumacher, Martin M., Grussenmeyer, Thomas, Jenoe, Paul, Hartmann, Nicole, Moes, Suzette, Letzkus, Martin, Bitzer, Johannes, Lefkovits, Ivan, Staedtler, Frank, Zhong, Xiao Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208622/
https://www.ncbi.nlm.nih.gov/pubmed/22076154
http://dx.doi.org/10.1371/journal.pone.0027355

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