p53 Dependent Centrosome Clustering Prevents Multipolar Mitosis in Tetraploid Cells

BACKGROUND: p53 abnormality and aneuploidy often coexist in human tumors, and tetraploidy is considered as an intermediate between normal diploidy and aneuploidy. The purpose of this study was to investigate whether and how p53 influences the transformation from tetraploidy to aneuploidy. PRINCIPAL...

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Detalles Bibliográficos
Autores principales: Yi, Qiyi, Zhao, Xiaoyu, Huang, Yun, Ma, Tieliang, Zhang, Yingyin, Hou, Heli, Cooke, Howard J., Yang, Da-Qing, Wu, Mian, Shi, Qinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208627/
https://www.ncbi.nlm.nih.gov/pubmed/22076149
http://dx.doi.org/10.1371/journal.pone.0027304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208627/
https://www.ncbi.nlm.nih.gov/pubmed/22076149
http://dx.doi.org/10.1371/journal.pone.0027304

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