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p53 Dependent Centrosome Clustering Prevents Multipolar Mitosis in Tetraploid Cells
BACKGROUND: p53 abnormality and aneuploidy often coexist in human tumors, and tetraploidy is considered as an intermediate between normal diploidy and aneuploidy. The purpose of this study was to investigate whether and how p53 influences the transformation from tetraploidy to aneuploidy. PRINCIPAL...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208627/ https://www.ncbi.nlm.nih.gov/pubmed/22076149 http://dx.doi.org/10.1371/journal.pone.0027304 |