Antidepressants Stimulate Hippocampal Neurogenesis by Inhibiting p21 Expression in the Subgranular Zone of the Hipppocampus

The relationships among hippocampal neurogenesis, depression and the mechanism of action of antidepressant drugs have generated a considerable amount of controversy. The cyclin-dependent kinase (Cdk) inhibitor p21(Cip1) (p21) plays a crucial role in restraining cellular proliferation and maintaining...

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Detalles Bibliográficos
Autores principales: Pechnick, Robert N., Zonis, Svetlana, Wawrowsky, Kolja, Cosgayon, Rosemarie, Farrokhi, Catherine, Lacayo, Liliana, Chesnokova, Vera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208633/
https://www.ncbi.nlm.nih.gov/pubmed/22076148
http://dx.doi.org/10.1371/journal.pone.0027290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208633/
https://www.ncbi.nlm.nih.gov/pubmed/22076148
http://dx.doi.org/10.1371/journal.pone.0027290

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