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Effect of pregestational maternal, obstetric and perinatal factors on neonatal outcome in extreme prematurity

PURPOSE: To investigate the effect of pregestational maternal, obstetric and perinatal factors on neonatal outcome in extreme preterm deliveries. METHODS: Retrospective study of deliveries in a Norwegian tertiary teaching hospital. All women with live births at 24(+0)– 27(+6) weeks of gestation betw...

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Detalles Bibliográficos
Autores principales: Wang, Yun, Tanbo, Tom, Ellingsen, Liv, Åbyholm, Thomas, Henriksen, Tore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208820/
https://www.ncbi.nlm.nih.gov/pubmed/21387086
http://dx.doi.org/10.1007/s00404-011-1870-5
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author Wang, Yun
Tanbo, Tom
Ellingsen, Liv
Åbyholm, Thomas
Henriksen, Tore
author_facet Wang, Yun
Tanbo, Tom
Ellingsen, Liv
Åbyholm, Thomas
Henriksen, Tore
author_sort Wang, Yun
collection PubMed
description PURPOSE: To investigate the effect of pregestational maternal, obstetric and perinatal factors on neonatal outcome in extreme preterm deliveries. METHODS: Retrospective study of deliveries in a Norwegian tertiary teaching hospital. All women with live births at 24(+0)– 27(+6) weeks of gestation between 2004 and 2007 were included. Major morbidity is defined as intraventricular haemorrhage grade 3–4, periventricular leukomalacia, bronchopulmonary dysplasia or necrotizing enterocolitis. Pregestational maternal, obstetric and perinatal variables were initially compared for mortality and survival with major morbidity at 24-h, 7- or 28-day postpartum/discharge in univariate analysis. Then, a multivariate analysis was conducted in order to determine independent factors associated with mortality and survival with major morbidity. RESULTS: A total of 109 babies were delivered alive in 92 women, representing 1.6% of total births. The survival rates were 93.6, 84.4 and 80.7%, with a prevalence of major morbidity among survivors of 40.4, 32.1 and 39.4% at 24-h, 7- and 30-day postpartum/discharge, respectively. After adjustment using multiple logistic regression, only a 5-min Apgar score ≤3 and babies with at least one major morbidity had significantly independent effects on neonatal survival. Multiple pregnancy and gestational age <26 weeks were the only two independent risk factors for survival with major morbidity. CONCLUSIONS: Neonatal survival was significantly predicted by a 5-min Apgar score and neonatal morbidity, independent of pregestational maternal disease, obstetric complications, method of delivery, gestational age and birth weight in extreme preterm deliveries. The excess morbidity rate was confined among multiples and babies who were delivered before 26 weeks of gestation.
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spelling pubmed-32088202011-11-28 Effect of pregestational maternal, obstetric and perinatal factors on neonatal outcome in extreme prematurity Wang, Yun Tanbo, Tom Ellingsen, Liv Åbyholm, Thomas Henriksen, Tore Arch Gynecol Obstet Materno-Fetal Medicine PURPOSE: To investigate the effect of pregestational maternal, obstetric and perinatal factors on neonatal outcome in extreme preterm deliveries. METHODS: Retrospective study of deliveries in a Norwegian tertiary teaching hospital. All women with live births at 24(+0)– 27(+6) weeks of gestation between 2004 and 2007 were included. Major morbidity is defined as intraventricular haemorrhage grade 3–4, periventricular leukomalacia, bronchopulmonary dysplasia or necrotizing enterocolitis. Pregestational maternal, obstetric and perinatal variables were initially compared for mortality and survival with major morbidity at 24-h, 7- or 28-day postpartum/discharge in univariate analysis. Then, a multivariate analysis was conducted in order to determine independent factors associated with mortality and survival with major morbidity. RESULTS: A total of 109 babies were delivered alive in 92 women, representing 1.6% of total births. The survival rates were 93.6, 84.4 and 80.7%, with a prevalence of major morbidity among survivors of 40.4, 32.1 and 39.4% at 24-h, 7- and 30-day postpartum/discharge, respectively. After adjustment using multiple logistic regression, only a 5-min Apgar score ≤3 and babies with at least one major morbidity had significantly independent effects on neonatal survival. Multiple pregnancy and gestational age <26 weeks were the only two independent risk factors for survival with major morbidity. CONCLUSIONS: Neonatal survival was significantly predicted by a 5-min Apgar score and neonatal morbidity, independent of pregestational maternal disease, obstetric complications, method of delivery, gestational age and birth weight in extreme preterm deliveries. The excess morbidity rate was confined among multiples and babies who were delivered before 26 weeks of gestation. Springer-Verlag 2011-03-09 2011 /pmc/articles/PMC3208820/ /pubmed/21387086 http://dx.doi.org/10.1007/s00404-011-1870-5 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Materno-Fetal Medicine
Wang, Yun
Tanbo, Tom
Ellingsen, Liv
Åbyholm, Thomas
Henriksen, Tore
Effect of pregestational maternal, obstetric and perinatal factors on neonatal outcome in extreme prematurity
title Effect of pregestational maternal, obstetric and perinatal factors on neonatal outcome in extreme prematurity
title_full Effect of pregestational maternal, obstetric and perinatal factors on neonatal outcome in extreme prematurity
title_fullStr Effect of pregestational maternal, obstetric and perinatal factors on neonatal outcome in extreme prematurity
title_full_unstemmed Effect of pregestational maternal, obstetric and perinatal factors on neonatal outcome in extreme prematurity
title_short Effect of pregestational maternal, obstetric and perinatal factors on neonatal outcome in extreme prematurity
title_sort effect of pregestational maternal, obstetric and perinatal factors on neonatal outcome in extreme prematurity
topic Materno-Fetal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208820/
https://www.ncbi.nlm.nih.gov/pubmed/21387086
http://dx.doi.org/10.1007/s00404-011-1870-5
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