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Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments
Hypoxia and oncogene expression both stimulate glycolytic metabolism in tumors, thereby leading to lactate production. However, lactate is more than merely a by-product of glycolysis: it can be used as a metabolic fuel by oxidative cancer cells. This phenomenon resembles processes that have been des...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Company of Biologists Limited
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209642/ https://www.ncbi.nlm.nih.gov/pubmed/22065843 http://dx.doi.org/10.1242/dmm.007724 |