Clinical utility of clodronate in the prevention and management of osteoporosis in patients intolerant of oral bisphosphonates

Bisphosphonates have a long history in the treatment of osteoporosis and bone-related disease. This review focuses on the use of a specific nonaminobisphosphonate, clodronate, which appears to be much better tolerated than other bisphosphonates and free of high-risk contraindications. Specifically,...

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Autores principales: Muratore, Maurizio, Quarta, Eugenio, Grimaldi, Antonella, Calcagnile, Fabio, Quarta, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210073/
https://www.ncbi.nlm.nih.gov/pubmed/22087064
http://dx.doi.org/10.2147/DDDT.S12139
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author Muratore, Maurizio
Quarta, Eugenio
Grimaldi, Antonella
Calcagnile, Fabio
Quarta, Laura
author_facet Muratore, Maurizio
Quarta, Eugenio
Grimaldi, Antonella
Calcagnile, Fabio
Quarta, Laura
author_sort Muratore, Maurizio
collection PubMed
description Bisphosphonates have a long history in the treatment of osteoporosis and bone-related disease. This review focuses on the use of a specific nonaminobisphosphonate, clodronate, which appears to be much better tolerated than other bisphosphonates and free of high-risk contraindications. Specifically, this paper reviews its use in the prevention of osteoporosis in postmenopausal women, taking into account its tolerability profile and recent safety issues arising regarding the use of bisphosphonates.
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spelling pubmed-32100732011-11-15 Clinical utility of clodronate in the prevention and management of osteoporosis in patients intolerant of oral bisphosphonates Muratore, Maurizio Quarta, Eugenio Grimaldi, Antonella Calcagnile, Fabio Quarta, Laura Drug Des Devel Ther Review Bisphosphonates have a long history in the treatment of osteoporosis and bone-related disease. This review focuses on the use of a specific nonaminobisphosphonate, clodronate, which appears to be much better tolerated than other bisphosphonates and free of high-risk contraindications. Specifically, this paper reviews its use in the prevention of osteoporosis in postmenopausal women, taking into account its tolerability profile and recent safety issues arising regarding the use of bisphosphonates. Dove Medical Press 2011-10-19 /pmc/articles/PMC3210073/ /pubmed/22087064 http://dx.doi.org/10.2147/DDDT.S12139 Text en © 2011 Muratore et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Muratore, Maurizio
Quarta, Eugenio
Grimaldi, Antonella
Calcagnile, Fabio
Quarta, Laura
Clinical utility of clodronate in the prevention and management of osteoporosis in patients intolerant of oral bisphosphonates
title Clinical utility of clodronate in the prevention and management of osteoporosis in patients intolerant of oral bisphosphonates
title_full Clinical utility of clodronate in the prevention and management of osteoporosis in patients intolerant of oral bisphosphonates
title_fullStr Clinical utility of clodronate in the prevention and management of osteoporosis in patients intolerant of oral bisphosphonates
title_full_unstemmed Clinical utility of clodronate in the prevention and management of osteoporosis in patients intolerant of oral bisphosphonates
title_short Clinical utility of clodronate in the prevention and management of osteoporosis in patients intolerant of oral bisphosphonates
title_sort clinical utility of clodronate in the prevention and management of osteoporosis in patients intolerant of oral bisphosphonates
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210073/
https://www.ncbi.nlm.nih.gov/pubmed/22087064
http://dx.doi.org/10.2147/DDDT.S12139
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