Cargando…

Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor

BACKGROUND: uPA/uPAR is a multifunctional system that is over expressed in many cancers and plays a critical role in glioblastoma (GBM) invasion. Previous studies from our lab have also shown that uPA/uPAR down regulation inhibits cancer cell invasion in SNB 19 GBM cells. METHODS: As Notch 1 is know...

Descripción completa

Detalles Bibliográficos
Autores principales:	Raghu, Hari, Gondi, Christopher S, Dinh, Dzung H, Gujrati, Meena, Rao, Jasti S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210098/ https://www.ncbi.nlm.nih.gov/pubmed/22004682 http://dx.doi.org/10.1186/1476-4598-10-130

Ejemplares similares

Suppression of uPA and uPAR Attenuates Angiogenin Mediated Angiogenesis in Endothelial and Glioblastoma Cell Lines
por: Raghu, Hari, et al.
Publicado: (2010)

Cathepsin B and uPAR Knockdown Inhibits Tumor-induced Angiogenesis by Modulating VEGF Expression in Glioma
por: Malla, Rama Rao, et al.
Publicado: (2011)

The uPA/uPAR system in astrocytic wound healing
por: Yepes, Manuel
Publicado: (2022)

MMP-9, uPAR and Cathepsin B Silencing Downregulate Integrins in Human Glioma Xenograft Cells In Vitro and In Vivo in Nude Mice
por: Veeravalli, Krishna Kumar, et al.
Publicado: (2010)

COVID-19 and pneumonia: a role for the uPA/uPAR system
por: D’Alonzo, Daniele, et al.
Publicado: (2020)

Apoptosis Induced by Knockdown of uPAR and MMP-9 is Mediated by Inactivation of EGFR/STAT3 Signaling in Medulloblastoma
por: Kotipatruni, Ramaprasada Rao, et al.
Publicado: (2012)

Downregulation of uPAR and Cathepsin B Induces Apoptosis via Regulation of Bcl-2 and Bax and Inhibition of the PI3K/Akt Pathway in Gliomas
por: Malla, Ramarao, et al.
Publicado: (2010)

Correction: Downregulation of uPAR and Cathepsin B Induces Apoptosis via Regulation of Bcl-2 and Bax and Inhibition of the PI3K/Akt Pathway in Gliomas
por: Malla, Ramarao, et al.
Publicado: (2014)

Effects of ulinastatin and docetaxel on breast cancer invasion and expression of uPA, uPAR and ERK
por: Luo, Jie, et al.
Publicado: (2011)

Antibody-based PET of uPA/uPAR signaling with broad applicability for cancer imaging
por: Yang, Dongzhi, et al.
Publicado: (2016)

Prognostic significance of uPA and uPAR expression in patients with cervical cancer undergoing radiotherapy
por: Nantajit, Danupon, et al.
Publicado: (2021)

Suppression of uPAR Retards Radiation-Induced Invasion and Migration Mediated by Integrin β1/FAK Signaling in Medulloblastoma
por: Nalla, Arun Kumar, et al.
Publicado: (2010)

Snail mediates invasion through uPA/uPAR and the MAPK signaling pathway in prostate cancer cells
por: RANDLE, DIANDRA D., et al.
Publicado: (2013)

Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) promote neurorepair in the ischemic brain
por: Merino, Paola, et al.
Publicado: (2017)

TGF-β regulation of the uPA/uPAR axis modulates mesothelial-mesenchymal transition (MesoMT)
por: Logan, Ranisha, et al.
Publicado: (2021)

Targeting uPA-uPAR interaction to improve intestinal epithelial barrier integrity in inflammatory bowel disease
por: Cheng, Yang, et al.
Publicado: (2021)

The uPA/uPAR System Orchestrates the Inflammatory Response, Vascular Homeostasis, and Immune System in Fibrosis Progression
por: Kanno, Yosuke
Publicado: (2023)

Co-Depletion of Cathepsin B and uPAR Induces G0/G1 Arrest in Glioma via FOXO3a Mediated p27(Kip1) Upregulation
por: Gopinath, Sreelatha, et al.
Publicado: (2010)

Oncogenic role of p53 is suppressed by si-RNA bicistronic construct of uPA, uPAR and cathepsin-B in meningiomas both in vitro and in vivo
por: Gupta, Reshu, et al.
Publicado: (2021)

uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy
por: Pavón, Miguel Angel, et al.
Publicado: (2016)

uPAR enhances malignant potential of triple-negative breast cancer by directly interacting with uPA and IGF1R
por: Huber, Michaela C., et al.
Publicado: (2016)

Multifaceted Role of the Urokinase-Type Plasminogen Activator (uPA) and Its Receptor (uPAR): Diagnostic, Prognostic, and Therapeutic Applications
por: Mahmood, Niaz, et al.
Publicado: (2018)

Localization of uPAR and MMP-9 in lipid rafts is critical for migration, invasion and angiogenesis in human breast cancer cells
por: Raghu, Hari, et al.
Publicado: (2010)

Multifunctional roles of urokinase plasminogen activator (uPA) in cancer stemness and chemoresistance of pancreatic cancer
por: Asuthkar, Swapna, et al.
Publicado: (2013)

TEM8 functions as a receptor for uPA and mediates uPA-stimulated EGFR phosphorylation
por: Zhang, Lian-Cheng, et al.
Publicado: (2018)

The Association of uPA, uPAR, and suPAR System with Inflammation and Joint Damage in Rheumatoid Arthritis: suPAR as a Biomarker in the Light of a Personalized Medicine Perspective
por: Benucci, Maurizio, et al.
Publicado: (2022)

MMP-9 and uPAR regulated glioma cell migration
por: Veeravalli, Krishna Kumar, et al.
Publicado: (2012)

Independent validation of stromal uPA in ABCSG-08: Level 1b evidence for the prognostic value of uPA immunohistochemistry
por: Singer, C.F., et al.
Publicado: (2022)

Construction of a Single Lentiviral Vector Containing Tetracycline-Inducible Alb-uPA for Transduction of uPA Expression in Murine Hepatocytes
por: Bai, Jiasi, et al.
Publicado: (2013)

Degradation of Internalized αvβ5 Integrin Is Controlled by uPAR Bound uPA: Effect on β1 Integrin Activity and α-SMA Stress Fiber Assembly
por: Wang, Lingyan, et al.
Publicado: (2012)

Melatonin exerts anti-fibrinolytic effects by regulating IL-1β-induced changes in uPA, uPAR, and PAI-1 expression/production in human dental pulp cells
por: Chang, Mei-Chi, et al.
Publicado: (2022)

uPA-mediated plasminogen activation is enhanced by polyphosphate
por: Whyte, Claire S., et al.
Publicado: (2020)

Tumor-associated soluble uPAR-directed endothelial cell motility and tumor angiogenesis
por: Rao, J S, et al.
Publicado: (2013)

Expression of uPA, tPA, and PAI-1 in Calcified Aortic Valves
por: Kochtebane, Najlah, et al.
Publicado: (2014)

uPAR and cathepsin B knockdown inhibits radiation-induced PKC integrated integrin signaling to the cytoskeleton of glioma-initiating cells
por: ALAPATI, KIRANMAI, et al.
Publicado: (2012)

Quercetin Has Antimetastatic Effects on Gastric Cancer Cells via the Interruption of uPA/uPAR Function by Modulating NF-κb, PKC-δ, ERK1/2, and AMPKα
por: Li, Hai, et al.
Publicado: (2017)

uPA deficiency exacerbates muscular dystrophy in MDX mice
por: Suelves, Mònica, et al.
Publicado: (2007)

uPA deficiency exacerbates muscular dystrophy in MDX mice
por: Suelves, Mònica, et al.
Publicado: (2007)

Integrin is on uPAR to unleash cells
por: LeBrasseur, Nicole
Publicado: (2003)

uPAR's signaling two step
por: Leslie, Mitch
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_cbqjgkhoqm1sfmqhn4l1qoeqtr