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An asymmetric interface between the regulatory particle and core particle of the proteasome
The S. cerevisiae proteasome comprises a 19-subunit regulatory particle (RP) and 28-subunit core particle (CP). To be degraded, substrates must cross the CP-RP interface, a site of complex conformational changes and regulatory events. This interface includes two aligned heteromeric rings: the six AT...
Autores principales: | Tian, Geng, Park, Soyeon, Lee, Min Jae, Huck, Bettina, McAllister, Fiona, Hill, Christopher P., Gygi, Steven P., Finley, Daniel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210322/ https://www.ncbi.nlm.nih.gov/pubmed/22037170 http://dx.doi.org/10.1038/nsmb.2147 |
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