Cargando…

Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

AIM/HYPOTHESIS: The glucose-lowering drug metformin has been shown to activate hepatic AMP-activated protein kinase (AMPK), a master kinase regulating cellular energy homeostasis. However, the underlying mechanisms remain controversial and have never been investigated in primary human hepatocytes. M...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stephenne, X., Foretz, M., Taleux, N., van der Zon, G. C., Sokal, E., Hue, L., Viollet, B., Guigas, B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210354/ https://www.ncbi.nlm.nih.gov/pubmed/21947382 http://dx.doi.org/10.1007/s00125-011-2311-5

Ejemplares similares

Metformin: update on mechanisms of action and repurposing potential
por: Foretz, Marc, et al.
Publicado: (2023)

Adenosine-Mono-Phosphate-Activated Protein Kinase-Independent Effects of Metformin in T Cells
por: Zarrouk, Marouan, et al.
Publicado: (2014)

AMPK is not required for the effect of metformin on the inhibition of BMP6-induced hepcidin gene expression in hepatocytes
por: Deschemin, Jean-Christophe, et al.
Publicado: (2017)

AMP-Activated Protein Kinase Signalling
por: Neumann, Dietbert, et al.
Publicado: (2019)

Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation
por: Moonira, Tabassum, et al.
Publicado: (2020)

Biguanides suppress hepatic glucagon signaling by decreasing production of cyclic AMP
por: Miller, Russell A., et al.
Publicado: (2013)

Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation
por: Hasenour, Clinton M., et al.
Publicado: (2017)

AMP-Activated Protein Kinase–Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol
por: Um, Jee-Hyun, et al.
Publicado: (2010)

Correction: Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation
por: Hasenour, Clinton M., et al.
Publicado: (2017)

Specific Deletion of AMP-Activated Protein Kinase (α1AMPK) in Murine Oocytes Alters Junctional Protein Expression and Mitochondrial Physiology
por: Bertoldo, Michael J., et al.
Publicado: (2015)

Finely-tuned regulation of AMP-activated protein kinase is crucial for human adult erythropoiesis
por: Ladli, Meriem, et al.
Publicado: (2019)

Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms
por: Chen, Suet Ching, et al.
Publicado: (2017)

Role of Cardiac AMP-Activated Protein Kinase in a Non-pathological Setting: Evidence From Cardiomyocyte-Specific, Inducible AMP-Activated Protein Kinase α1α2-Knockout Mice
por: Tokarska-Schlattner, Malgorzata, et al.
Publicado: (2021)

AMP-activated protein kinase α1 protects against diet-induced insulin resistance and obesity. Diabetes 2012;61:3114–3125
por: Zhang, W, et al.
Publicado: (2013)

Defining the Contribution of AMP-activated Protein Kinase (AMPK) and Protein Kinase C (PKC) in Regulation of Glucose Uptake by Metformin in Skeletal Muscle Cells
por: Turban, Sophie, et al.
Publicado: (2012)

Atrial AMP-activated protein kinase is critical for prevention of dysregulation of electrical excitability and atrial fibrillation
por: Su, Kevin N., et al.
Publicado: (2022)

Metformin Sensitizes Leukemia Cells to Vincristine via Activation of AMP-activated Protein Kinase
por: Yi, Yong, et al.
Publicado: (2017)

Metformin Augments Panobinostat's Anti-Bladder Cancer Activity by Activating AMP-Activated Protein Kinase()()
por: Okubo, Kazuki, et al.
Publicado: (2019)

AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B
por: Johanns, M., et al.
Publicado: (2016)

AMP Activated Protein Kinase Is Indispensable for Myocardial Adaptation to Caloric Restriction in Mice
por: Chen, Kai, et al.
Publicado: (2013)

Activation of AMP-activated protein kinase signaling pathway ameliorates steatosis in laying hen hepatocytes
por: Zhang, Kun, et al.
Publicado: (2020)

AMP-Activated Protein Kinase α1 Protects Against Diet-Induced Insulin Resistance and Obesity
por: Zhang, Weiyu, et al.
Publicado: (2012)

Activation of AMPK for a Break in Hepatic Lipid Accumulation and Circulating Cholesterol
por: Foretz, Marc, et al.
Publicado: (2018)

Deletion of intestinal epithelial AMP-activated protein kinase alters distal colon permeability but not glucose homeostasis
por: Olivier, Séverine, et al.
Publicado: (2021)

In Vivo Activation of AMP-Activated Protein Kinase Attenuates Diabetes-Enhanced Degradation of GTP Cyclohydrolase I
por: Wang, Shuangxi, et al.
Publicado: (2009)

A Novel Cardioprotective Agent in Cardiac Transplantation: Metformin Activation of AMP-Activated Protein Kinase Decreases Acute Ischemia-Reperfusion Injury and Chronic Rejection
por: Chin, Jocelyn T., et al.
Publicado: (2011)

Decreased AMP‐activated protein kinase (AMPK) function and protective effect of metformin in neonatal rat pups exposed to hyperoxia lung injury
por: Yadav, Abha, et al.
Publicado: (2020)

A possible role for AMP-activated protein kinase activated by metformin and AICAR in human granulosa cells
por: Kai, Yufuko, et al.
Publicado: (2015)

AMP‐activated protein kinase: a cellular energy sensor that comes in 12 flavours
por: Ross, Fiona A., et al.
Publicado: (2016)

Acetic Acid Activates the AMP-Activated Protein Kinase Signaling Pathway to Regulate Lipid Metabolism in Bovine Hepatocytes
por: Li, Xinwei, et al.
Publicado: (2013)

Activated AMP-activated protein kinase prevents hepatic steatosis, oxidative stress and inflammation in primary chicken hepatocytes
por: Yao, Yao, et al.
Publicado: (2022)

AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo
por: Domise, Manon, et al.
Publicado: (2016)

Metformin: Activation of 5′ AMP-activated protein kinase and its emerging potential beyond anti-hyperglycemic action
por: Goel, Sanjay, et al.
Publicado: (2022)

Elevated basal AMP-activated protein kinase activity sensitizes colorectal cancer cells to growth inhibition by metformin
por: Morrison, Kaitlin R., et al.
Publicado: (2023)

Metformin improves boar sperm quality via 5′-AMP-activated protein kinase-mediated energy metabolism in vitro
por: Li, Rong-Nan, et al.
Publicado: (2020)

AMP-activated protein kinase deficiency reduces ozone-induced lung injury and oxidative stress in mice
por: Hulo, Sébastien, et al.
Publicado: (2011)

Corrigendum to “Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms” [Mol. Cell. Endocrinol. 440 15 January 2017 57–68]
por: Chen, S.C., et al.
Publicado: (2017)

Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression
por: Osawa, Yosuke, et al.
Publicado: (2011)

Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 & 2 and AMP-activated Protein Kinase in the Kidney
por: Christensen, Michael, et al.
Publicado: (2016)

AMPK Activation Reduces Hepatic Lipid Content by Increasing Fat Oxidation In Vivo
por: Foretz, Marc, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_605aban1ch9kh34040t364i9ae