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Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

AIM/HYPOTHESIS: The glucose-lowering drug metformin has been shown to activate hepatic AMP-activated protein kinase (AMPK), a master kinase regulating cellular energy homeostasis. However, the underlying mechanisms remain controversial and have never been investigated in primary human hepatocytes. M...

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Detalles Bibliográficos
Autores principales:	Stephenne, X., Foretz, M., Taleux, N., van der Zon, G. C., Sokal, E., Hue, L., Viollet, B., Guigas, B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210354/ https://www.ncbi.nlm.nih.gov/pubmed/21947382 http://dx.doi.org/10.1007/s00125-011-2311-5

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