Peptide Neurotoxins that Affect Voltage-Gated Calcium Channels: A Close-Up on ω-Agatoxins

Peptide neurotoxins found in animal venoms have gained great interest in the field of neurotransmission. As they are high affinity ligands for calcium, potassium and sodium channels, they have become useful tools for studying channel structure and activity. Peptide neurotoxins represent the clinical...

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Detalles Bibliográficos
Autores principales: Pringos, Emilie, Vignes, Michel, Martinez, Jean, Rolland, Valerie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210452/
https://www.ncbi.nlm.nih.gov/pubmed/22069688
http://dx.doi.org/10.3390/toxins3010017
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author Pringos, Emilie
Vignes, Michel
Martinez, Jean
Rolland, Valerie
author_facet Pringos, Emilie
Vignes, Michel
Martinez, Jean
Rolland, Valerie
author_sort Pringos, Emilie
collection PubMed
description Peptide neurotoxins found in animal venoms have gained great interest in the field of neurotransmission. As they are high affinity ligands for calcium, potassium and sodium channels, they have become useful tools for studying channel structure and activity. Peptide neurotoxins represent the clinical potential of ion-channel modulators across several therapeutic fields, especially in developing new strategies for treatment of ion channel-related diseases. The aim of this review is to overview the latest updates in the domain of peptide neurotoxins that affect voltage-gated calcium channels, with a special focus on ω-agatoxins.
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spelling pubmed-32104522011-11-08 Peptide Neurotoxins that Affect Voltage-Gated Calcium Channels: A Close-Up on ω-Agatoxins Pringos, Emilie Vignes, Michel Martinez, Jean Rolland, Valerie Toxins (Basel) Review Peptide neurotoxins found in animal venoms have gained great interest in the field of neurotransmission. As they are high affinity ligands for calcium, potassium and sodium channels, they have become useful tools for studying channel structure and activity. Peptide neurotoxins represent the clinical potential of ion-channel modulators across several therapeutic fields, especially in developing new strategies for treatment of ion channel-related diseases. The aim of this review is to overview the latest updates in the domain of peptide neurotoxins that affect voltage-gated calcium channels, with a special focus on ω-agatoxins. MDPI 2011-01-04 /pmc/articles/PMC3210452/ /pubmed/22069688 http://dx.doi.org/10.3390/toxins3010017 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Pringos, Emilie
Vignes, Michel
Martinez, Jean
Rolland, Valerie
Peptide Neurotoxins that Affect Voltage-Gated Calcium Channels: A Close-Up on ω-Agatoxins
title Peptide Neurotoxins that Affect Voltage-Gated Calcium Channels: A Close-Up on ω-Agatoxins
title_full Peptide Neurotoxins that Affect Voltage-Gated Calcium Channels: A Close-Up on ω-Agatoxins
title_fullStr Peptide Neurotoxins that Affect Voltage-Gated Calcium Channels: A Close-Up on ω-Agatoxins
title_full_unstemmed Peptide Neurotoxins that Affect Voltage-Gated Calcium Channels: A Close-Up on ω-Agatoxins
title_short Peptide Neurotoxins that Affect Voltage-Gated Calcium Channels: A Close-Up on ω-Agatoxins
title_sort peptide neurotoxins that affect voltage-gated calcium channels: a close-up on ω-agatoxins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210452/
https://www.ncbi.nlm.nih.gov/pubmed/22069688
http://dx.doi.org/10.3390/toxins3010017
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AT rollandvalerie peptideneurotoxinsthataffectvoltagegatedcalciumchannelsacloseuponōagatoxins

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