The Discodermia calyx Toxin Calyculin A Enhances Cyclin D1 Phosphorylation and Degradation, and Arrests Cell Cycle Progression in Human Breast Cancer Cells

Cyclin D1 is a key regulator of the cell cycle that is over expressed in more than half of breast cancer patients. The levels of cyclin D1 are controlled primarily through post-translational mechanisms and phosphorylation of cyclin D1 at T286 induces its proteasomal degradation. To date, no studies...

Descripción completa

Detalles Bibliográficos
Autores principales: Edelson, Jessica R., Brautigan, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210456/
https://www.ncbi.nlm.nih.gov/pubmed/22069692
http://dx.doi.org/10.3390/toxins3010105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210456/
https://www.ncbi.nlm.nih.gov/pubmed/22069692
http://dx.doi.org/10.3390/toxins3010105

Ejemplares similares