Is Neurodegenerative Disease a Long-Latency Response to Early-Life Genotoxin Exposure?
Western Pacific amyotrophic lateral sclerosis and parkinsonism-dementia complex, a disappearing neurodegenerative disease linked to use of the neurotoxic cycad plant for food and/or medicine, is intensively studied because the neuropathology (tauopathy) is similar to that of Alzheimer’s disease. Cyc...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Molecular Diversity Preservation International (MDPI)
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210588/ https://www.ncbi.nlm.nih.gov/pubmed/22073019 http://dx.doi.org/10.3390/ijerph8103889 |
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author | Kisby, Glen E. Spencer, Peter S. |
author_facet | Kisby, Glen E. Spencer, Peter S. |
author_sort | Kisby, Glen E. |
collection | PubMed |
description | Western Pacific amyotrophic lateral sclerosis and parkinsonism-dementia complex, a disappearing neurodegenerative disease linked to use of the neurotoxic cycad plant for food and/or medicine, is intensively studied because the neuropathology (tauopathy) is similar to that of Alzheimer’s disease. Cycads contain neurotoxic and genotoxic principles, notably cycasin and methylazoxymethanol, the latter sharing chemical relations with nitrosamines, which are derived from nitrates and nitrites in preserved meats and fertilizers, and also used in the rubber and leather industries. This review includes new data that influence understanding of the neurobiological actions of cycad and related genotoxins and the putative mechanisms by which they might trigger neurodegenerative disease. |
format | Online Article Text |
id | pubmed-3210588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-32105882011-11-09 Is Neurodegenerative Disease a Long-Latency Response to Early-Life Genotoxin Exposure? Kisby, Glen E. Spencer, Peter S. Int J Environ Res Public Health Review Western Pacific amyotrophic lateral sclerosis and parkinsonism-dementia complex, a disappearing neurodegenerative disease linked to use of the neurotoxic cycad plant for food and/or medicine, is intensively studied because the neuropathology (tauopathy) is similar to that of Alzheimer’s disease. Cycads contain neurotoxic and genotoxic principles, notably cycasin and methylazoxymethanol, the latter sharing chemical relations with nitrosamines, which are derived from nitrates and nitrites in preserved meats and fertilizers, and also used in the rubber and leather industries. This review includes new data that influence understanding of the neurobiological actions of cycad and related genotoxins and the putative mechanisms by which they might trigger neurodegenerative disease. Molecular Diversity Preservation International (MDPI) 2011-10 2011-09-29 /pmc/articles/PMC3210588/ /pubmed/22073019 http://dx.doi.org/10.3390/ijerph8103889 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Kisby, Glen E. Spencer, Peter S. Is Neurodegenerative Disease a Long-Latency Response to Early-Life Genotoxin Exposure? |
title | Is Neurodegenerative Disease a Long-Latency Response to Early-Life Genotoxin Exposure? |
title_full | Is Neurodegenerative Disease a Long-Latency Response to Early-Life Genotoxin Exposure? |
title_fullStr | Is Neurodegenerative Disease a Long-Latency Response to Early-Life Genotoxin Exposure? |
title_full_unstemmed | Is Neurodegenerative Disease a Long-Latency Response to Early-Life Genotoxin Exposure? |
title_short | Is Neurodegenerative Disease a Long-Latency Response to Early-Life Genotoxin Exposure? |
title_sort | is neurodegenerative disease a long-latency response to early-life genotoxin exposure? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210588/ https://www.ncbi.nlm.nih.gov/pubmed/22073019 http://dx.doi.org/10.3390/ijerph8103889 |
work_keys_str_mv | AT kisbyglene isneurodegenerativediseasealonglatencyresponsetoearlylifegenotoxinexposure AT spencerpeters isneurodegenerativediseasealonglatencyresponsetoearlylifegenotoxinexposure |