Bioactive Cembranoids from the Soft Coral Sinularia crassa

Eight new cembranoids, crassarines A–H (1–8) were isolated from the Formosan soft coral Sinularia crassa. Compounds 1–3 represent the rare cembranoids with a 1,12-oxa-bridged tetrahydrofuran ring, while 4 and 5 are the firstly discovered 1,11-oxa-bridged tetrahydropyranocembranoids. The absolute con...

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Autores principales: Chao, Chih-Hua, Chou, Kuei-Ju, Huang, Chiung-Yao, Wen, Zhi-Hong, Hsu, Chi-Hsin, Wu, Yang-Chang, Dai, Chang-Feng, Sheu, Jyh-Horng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210613/
https://www.ncbi.nlm.nih.gov/pubmed/22073004
http://dx.doi.org/10.3390/md9101955
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author Chao, Chih-Hua
Chou, Kuei-Ju
Huang, Chiung-Yao
Wen, Zhi-Hong
Hsu, Chi-Hsin
Wu, Yang-Chang
Dai, Chang-Feng
Sheu, Jyh-Horng
author_facet Chao, Chih-Hua
Chou, Kuei-Ju
Huang, Chiung-Yao
Wen, Zhi-Hong
Hsu, Chi-Hsin
Wu, Yang-Chang
Dai, Chang-Feng
Sheu, Jyh-Horng
author_sort Chao, Chih-Hua
collection PubMed
description Eight new cembranoids, crassarines A–H (1–8) were isolated from the Formosan soft coral Sinularia crassa. Compounds 1–3 represent the rare cembranoids with a 1,12-oxa-bridged tetrahydrofuran ring, while 4 and 5 are the firstly discovered 1,11-oxa-bridged tetrahydropyranocembranoids. The absolute configuration of 6 was determined using the Mosher’s method. Compounds 6 and 8 were found to significantly inhibit the expression of both pro-inflammatory iNOS and COX-2 proteins at 10 μM, respectively, while compounds 4–8 were found to be non-cytotoxic toward the selected human liver cancer cells.
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spelling pubmed-32106132011-11-09 Bioactive Cembranoids from the Soft Coral Sinularia crassa Chao, Chih-Hua Chou, Kuei-Ju Huang, Chiung-Yao Wen, Zhi-Hong Hsu, Chi-Hsin Wu, Yang-Chang Dai, Chang-Feng Sheu, Jyh-Horng Mar Drugs Article Eight new cembranoids, crassarines A–H (1–8) were isolated from the Formosan soft coral Sinularia crassa. Compounds 1–3 represent the rare cembranoids with a 1,12-oxa-bridged tetrahydrofuran ring, while 4 and 5 are the firstly discovered 1,11-oxa-bridged tetrahydropyranocembranoids. The absolute configuration of 6 was determined using the Mosher’s method. Compounds 6 and 8 were found to significantly inhibit the expression of both pro-inflammatory iNOS and COX-2 proteins at 10 μM, respectively, while compounds 4–8 were found to be non-cytotoxic toward the selected human liver cancer cells. Molecular Diversity Preservation International 2011-10-17 /pmc/articles/PMC3210613/ /pubmed/22073004 http://dx.doi.org/10.3390/md9101955 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Chao, Chih-Hua
Chou, Kuei-Ju
Huang, Chiung-Yao
Wen, Zhi-Hong
Hsu, Chi-Hsin
Wu, Yang-Chang
Dai, Chang-Feng
Sheu, Jyh-Horng
Bioactive Cembranoids from the Soft Coral Sinularia crassa
title Bioactive Cembranoids from the Soft Coral Sinularia crassa
title_full Bioactive Cembranoids from the Soft Coral Sinularia crassa
title_fullStr Bioactive Cembranoids from the Soft Coral Sinularia crassa
title_full_unstemmed Bioactive Cembranoids from the Soft Coral Sinularia crassa
title_short Bioactive Cembranoids from the Soft Coral Sinularia crassa
title_sort bioactive cembranoids from the soft coral sinularia crassa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210613/
https://www.ncbi.nlm.nih.gov/pubmed/22073004
http://dx.doi.org/10.3390/md9101955
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