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Anti-Biofilm Compounds Derived from Marine Sponges

Bacterial biofilms are surface-attached communities of microorganisms that are protected by an extracellular matrix of biomolecules. In the biofilm state, bacteria are significantly more resistant to external assault, including attack by antibiotics. In their native environment, bacterial biofilms u...

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Autores principales: Stowe, Sean D., Richards, Justin J., Tucker, Ashley T., Thompson, Richele, Melander, Christian, Cavanagh, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210616/
https://www.ncbi.nlm.nih.gov/pubmed/22073007
http://dx.doi.org/10.3390/md9102010
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author Stowe, Sean D.
Richards, Justin J.
Tucker, Ashley T.
Thompson, Richele
Melander, Christian
Cavanagh, John
author_facet Stowe, Sean D.
Richards, Justin J.
Tucker, Ashley T.
Thompson, Richele
Melander, Christian
Cavanagh, John
author_sort Stowe, Sean D.
collection PubMed
description Bacterial biofilms are surface-attached communities of microorganisms that are protected by an extracellular matrix of biomolecules. In the biofilm state, bacteria are significantly more resistant to external assault, including attack by antibiotics. In their native environment, bacterial biofilms underpin costly biofouling that wreaks havoc on shipping, utilities, and offshore industry. Within a host environment, they are insensitive to antiseptics and basic host immune responses. It is estimated that up to 80% of all microbial infections are biofilm-based. Biofilm infections of indwelling medical devices are of particular concern, since once the device is colonized, infection is almost impossible to eliminate. Given the prominence of biofilms in infectious diseases, there is a notable effort towards developing small, synthetically available molecules that will modulate bacterial biofilm development and maintenance. Here, we highlight the development of small molecules that inhibit and/or disperse bacterial biofilms specifically through non-microbicidal mechanisms. Importantly, we discuss several sets of compounds derived from marine sponges that we are developing in our labs to address the persistent biofilm problem. We will discuss: discovery/synthesis of natural products and their analogues—including our marine sponge-derived compounds and initial adjuvant activity and toxicological screening of our novel anti-biofilm compounds.
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spelling pubmed-32106162011-11-09 Anti-Biofilm Compounds Derived from Marine Sponges Stowe, Sean D. Richards, Justin J. Tucker, Ashley T. Thompson, Richele Melander, Christian Cavanagh, John Mar Drugs Review Bacterial biofilms are surface-attached communities of microorganisms that are protected by an extracellular matrix of biomolecules. In the biofilm state, bacteria are significantly more resistant to external assault, including attack by antibiotics. In their native environment, bacterial biofilms underpin costly biofouling that wreaks havoc on shipping, utilities, and offshore industry. Within a host environment, they are insensitive to antiseptics and basic host immune responses. It is estimated that up to 80% of all microbial infections are biofilm-based. Biofilm infections of indwelling medical devices are of particular concern, since once the device is colonized, infection is almost impossible to eliminate. Given the prominence of biofilms in infectious diseases, there is a notable effort towards developing small, synthetically available molecules that will modulate bacterial biofilm development and maintenance. Here, we highlight the development of small molecules that inhibit and/or disperse bacterial biofilms specifically through non-microbicidal mechanisms. Importantly, we discuss several sets of compounds derived from marine sponges that we are developing in our labs to address the persistent biofilm problem. We will discuss: discovery/synthesis of natural products and their analogues—including our marine sponge-derived compounds and initial adjuvant activity and toxicological screening of our novel anti-biofilm compounds. Molecular Diversity Preservation International 2011-10-19 /pmc/articles/PMC3210616/ /pubmed/22073007 http://dx.doi.org/10.3390/md9102010 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Stowe, Sean D.
Richards, Justin J.
Tucker, Ashley T.
Thompson, Richele
Melander, Christian
Cavanagh, John
Anti-Biofilm Compounds Derived from Marine Sponges
title Anti-Biofilm Compounds Derived from Marine Sponges
title_full Anti-Biofilm Compounds Derived from Marine Sponges
title_fullStr Anti-Biofilm Compounds Derived from Marine Sponges
title_full_unstemmed Anti-Biofilm Compounds Derived from Marine Sponges
title_short Anti-Biofilm Compounds Derived from Marine Sponges
title_sort anti-biofilm compounds derived from marine sponges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210616/
https://www.ncbi.nlm.nih.gov/pubmed/22073007
http://dx.doi.org/10.3390/md9102010
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