Kinase Inhibitors from Marine Sponges

Protein kinases play a critical role in cell regulation and their deregulation is a contributing factor in an increasing list of diseases including cancer. Marine sponges have yielded over 70 novel compounds to date that exhibit significant inhibitory activity towards a range of protein kinases. The...

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Detalles Bibliográficos
Autores principales: Skropeta, Danielle, Pastro, Natalie, Zivanovic, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210622/
https://www.ncbi.nlm.nih.gov/pubmed/22073013
http://dx.doi.org/10.3390/md9102131
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author Skropeta, Danielle
Pastro, Natalie
Zivanovic, Ana
author_facet Skropeta, Danielle
Pastro, Natalie
Zivanovic, Ana
author_sort Skropeta, Danielle
collection PubMed
description Protein kinases play a critical role in cell regulation and their deregulation is a contributing factor in an increasing list of diseases including cancer. Marine sponges have yielded over 70 novel compounds to date that exhibit significant inhibitory activity towards a range of protein kinases. These compounds, which belong to diverse structural classes, are reviewed herein, and ordered based upon the kinase that they inhibit. Relevant synthetic studies on the marine natural product kinase inhibitors have also been included.
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spelling pubmed-32106222011-11-09 Kinase Inhibitors from Marine Sponges Skropeta, Danielle Pastro, Natalie Zivanovic, Ana Mar Drugs Review Protein kinases play a critical role in cell regulation and their deregulation is a contributing factor in an increasing list of diseases including cancer. Marine sponges have yielded over 70 novel compounds to date that exhibit significant inhibitory activity towards a range of protein kinases. These compounds, which belong to diverse structural classes, are reviewed herein, and ordered based upon the kinase that they inhibit. Relevant synthetic studies on the marine natural product kinase inhibitors have also been included. Molecular Diversity Preservation International 2011-10-24 /pmc/articles/PMC3210622/ /pubmed/22073013 http://dx.doi.org/10.3390/md9102131 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Skropeta, Danielle
Pastro, Natalie
Zivanovic, Ana
Kinase Inhibitors from Marine Sponges
title Kinase Inhibitors from Marine Sponges
title_full Kinase Inhibitors from Marine Sponges
title_fullStr Kinase Inhibitors from Marine Sponges
title_full_unstemmed Kinase Inhibitors from Marine Sponges
title_short Kinase Inhibitors from Marine Sponges
title_sort kinase inhibitors from marine sponges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210622/
https://www.ncbi.nlm.nih.gov/pubmed/22073013
http://dx.doi.org/10.3390/md9102131
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