Interplay between NS3 protease and human La protein regulates translation-replication switch of Hepatitis C virus

HCV NS3 protein plays a central role in viral polyprotein processing and RNA replication. We demonstrate that the NS3 protease (NS3(pro)) domain alone can specifically bind to HCV-IRES RNA, predominantly in the SLIV region. The cleavage activity of the NS3 protease domain is reduced upon HCV-RNA bin...

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Detalles Bibliográficos
Autores principales: Ray, Upasana, Das, Saumitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210691/
https://www.ncbi.nlm.nih.gov/pubmed/22355520
http://dx.doi.org/10.1038/srep00001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210691/
https://www.ncbi.nlm.nih.gov/pubmed/22355520
http://dx.doi.org/10.1038/srep00001

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